{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:18:50Z","timestamp":1790014730337,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Facial hyperpigmentation can negatively affect an individual's emotional and psychosocial well\u2010being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Assess safety and tolerability of a combination of microdermabrasion (DG) procedures using a novel brightening pro\u2010infusion serum (EC\u2010DG) with a targeted at\u2010home treatment regimen in subjects with mild to severe facial hyperpigmentation, including melasma, post\u2010inflammatory hyperpigmentation, and dark spots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>This 12\u2010week, open\u2010label study enrolled 18 subjects (Fitzpatrick skin types I\u2013IV) who underwent 6 in\u2010office DG procedures with EC\u2010DG (one procedure administered biweekly), along with daily topical application of a brightening treatment serum and dark spot cream. End points included change from baseline across multiple skin quality attributes and the Melasma Area and Severity Index (MASI), self\u2010assessment questionnaires, and tolerability assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The combination treatment was well tolerated and resulted in significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05) improvements from baseline in radiance, tactile roughness, and moisturization\/hydration immediately after the first treatment, in MASI score at day 3, and in overall hyperpigmentation at week 4. Most (94.1%) subjects were satisfied with treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DG procedures using EC\u2010DG combined with a targeted at\u2010home skincare regimen are effective and tolerable for treating facial hyperpigmentation across a broad range of skin types.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16192","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T03:53:44Z","timestamp":1706586824000},"page":"1726-1733","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and safety of novel topical pigment\u2010correcting regimen with biweekly diamond tip microdermabrasion procedures on facial hyperpigmentation"],"prefix":"10.1111","volume":"23","author":[{"given":"Lisa","family":"Goberdhan","sequence":"first","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Schneider","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth T.","family":"Makino","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arielle","family":"Bautista","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-5847","authenticated-orcid":false,"given":"Rahul C.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0239-8"},{"key":"e_1_2_13_3_1","first-page":"718","article-title":"Therapeutic insights in melasma and hyperpigmentation management","volume":"18","author":"Huerth KA","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14747"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0194-1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S385162"},{"key":"e_1_2_13_7_1","volume-title":"Postinflammatory Hyperpigmentation","author":"Lawrence 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