{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:13:33Z","timestamp":1792872813104,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transepidermal drug delivery is a novel therapeutic technique to boost efficacy of topical drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      In this clinical trial we evaluate the efficacy of the combination of fractional carbon dioxide (FCO\n                      <jats:sub>2<\/jats:sub>\n                      ) laser and bimatoprost solution compared to bimatoprost alone in the treatment of alopecia areata.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a prospective intra\u2010patient comparative randomized clinical trial on 20 patients with alopecia areata. In each participant two patches were chosen to randomly receive either topical 0.03% bimatoprost solution (twice a day for 12\u2009weeks) alone or in combination with FCO\n                      <jats:sub>2<\/jats:sub>\n                      laser (every 2\u2009weeks for 12\u2009weeks). Then response to treatment was evaluated by the measurement of the severity of alopecia tool score system (SALT) score, percentage of hair regrowth, physician assessment and patients' satisfaction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SALT score was reduced significantly during treatment sessions and after a 3\u2010month follow\u2010up in both treatment groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). The mean percentage of improvement in SALT score in the combination therapy and monotherapy groups were 46.43\u2009\u00b1\u20094.35% and 21.16\u2009\u00b1\u20094.06% at the end of the study and 46.42\u2009\u00b1\u20095.75% and16.11\u2009\u00b1\u20093.10% at the end of the follow\u2010up period, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). A general linear model of two\u2010way analysis demonstrated a significantly superior outcome in the combination therapy group compared to the monotherapy group during time (F\n                      <jats:sub>1.6, 13.2<\/jats:sub>\n                      \u2009=\u200943.8.\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fractional ablative laser can be considered as an assistant method for enhancing of efficacy of topical drugs especially in refractory cases of patchy alopecia areata.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16209","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:25:32Z","timestamp":1707276332000},"page":"1663-1668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The role of fractional laser\u2010assisted drug delivery in enhancing the efficacy of topical bimatoprost solution in the treatment of alopecia areata: An intra\u2010patient comparative randomized clinical trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Simin Shamsi","family":"Meymandi","sequence":"first","affiliation":[{"name":"Pathology and Stem Cell Research Center, Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Safari","sequence":"additional","affiliation":[{"name":"Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-7364","authenticated-orcid":false,"given":"Manzumeh Shamsi","family":"Meymandi","sequence":"additional","affiliation":[{"name":"Pathology and Stem Cell Research Center, Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-8682","authenticated-orcid":false,"given":"Mahin","family":"Aflatoonian","sequence":"additional","affiliation":[{"name":"Pathology and Stem Cell Research Center, Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14916"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"127","article-title":"Impact of demographic features and clinical factors on quality of life of patients with alopecia areata","volume":"26","author":"Khalili M","year":"2023","journal-title":"Iranian J Dermatol"},{"issue":"6","key":"e_1_2_12_4_1","article-title":"Fractional laser\u2010assisted hair regrowth and microneedling for the treatment of alopecia areata: a review","volume":"11","author":"Dabek RJ","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2412-6"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371416"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.EWX.0000444330.33581.2f"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14927"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14671"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14602"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1204a196"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_96_18"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-017-2306-7"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02417-0"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1525743"},{"issue":"1","key":"e_1_2_12_17_1","first-page":"37","article-title":"Transepidermal drug delivery: a new treatment option for areata alopecia? Journal of cosmetic and laser","volume":"17","author":"Issa MC","year":"2015","journal-title":"Therapy"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13742"},{"key":"e_1_2_12_19_1","unstructured":"HafizHS ElshahedLH AhmedHS.Bimatoprost versus triamcinolone acetonide with microneedling in the treatment of alopecia areata a comparative clinical and dermoscopic study."},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15569"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:37:11Z","timestamp":1777685831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jocd.16209"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16209","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,7]]},"assertion":[{"value":"2023-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}