{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:51:28Z","timestamp":1790801488665,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Topical therapy is the mainstay treatment of acne, and topical retinoids such as tretinoin, tazarotene, and adapalene are recommended as the first\u2010line therapy for mild to moderate acne. However, the cutaneous irritations may occur, and the dermocosmetics are recommended to prevent side effects of anti\u2010acne drugs and adhere to treatment. Thus, this study aims to compare the efficacy and tolerability of ceramides and niacinamide\u2010containing moisturizer (CCM) versus hydrophilic cream in combination with topical anti\u2010acne treatment in mild to moderate acne vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an 8\u2010week, randomized, double\u2010blinded, split face study in 40 patients assigned for topical anti\u2010acne medications (5% benzoyl peroxide and 0.1% adapalene gel), then randomly applied CCM or hydrophilic cream. All patients were followed at week 0, 2, 4, and 8 for acne improvement, adverse reactions, biometric, and biophysical evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>CCM could significantly improve the non\u2010inflammatory, inflammatory, and total acne lesions compared with hydrophilic cream after week 8 of treatment. Interestingly, there was an improvement of global worst score, hemoglobin index, melanin index, TEWL, skin hydration, sebum production, and skin surface pH, with no statistically significant differences between the two treatments. No serious side effects from clinical application of CCM and hydrophilic cream in mild to moderate acne vulgaris patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ceramide and niacinamide\u2010containing moisturizer in combination with anti\u2010acne medication can significantly improve acne lesions and decrease cutaneous irritations toward a satisfactory treatment outcome of mild to moderate acne vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16212","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:34:40Z","timestamp":1706765680000},"page":"1758-1765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Efficacy of ceramides and niacinamide\u2010containing moisturizer versus hydrophilic cream in combination with topical anti\u2010acne treatment in mild to moderate acne vulgaris: A split face, double\u2010blinded, randomized controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-2135","authenticated-orcid":false,"given":"Therdpong","family":"Tempark","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine King Chulalongkorn Memorial Hospital, Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Shem","sequence":"additional","affiliation":[{"name":"M. Yamin Clinic and Pharmacy JI. M. Yamin  Samarinda Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2982","authenticated-orcid":false,"given":"Suparuj","family":"Lueangarun","sequence":"additional","affiliation":[{"name":"Department of Aesthetic Medicine, College of Integrative Medicine Dhurakij Pundit University  Bangkok Thailand"},{"name":"Division of Dermatology, DeMed Clinic Center  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.618"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.1390s2048.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200464130-00005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70054-9"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12856"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12168"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13579"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13090"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.661037"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1079298"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01262335"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12456327"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.12.002"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12720"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"18","article-title":"Moisturizers and ceramide\u2010containing moisturizers may offer concomitant therapy with benefits","volume":"7","author":"Lynde CW","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"issue":"1","key":"e_1_2_12_17_1","first-page":"87","article-title":"The effect of ceramide\u2010containing skin care products on eczema resolution duration","volume":"81","author":"Draelos ZD","year":"2008","journal-title":"Cutis"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2007.00378.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170600717704"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12481"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04449.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02375.x"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/379173"},{"issue":"7","key":"e_1_2_12_24_1","first-page":"27","article-title":"Efficacy and tolerability of topical nicotinamide plus antibacterial adhesive agents and zinc\u2010pyrrolidone carboxylic acid versus placebo as an adjuvant treatment for moderate acne vulgaris in Indonesia: a multicenter, double\u2010blind, randomized, Controlled Trial","volume":"13","author":"Sitohang IBS","year":"2020","journal-title":"J Clin Aesthet Dermatol"},{"issue":"2","key":"e_1_2_12_25_1","first-page":"22","article-title":"How much do we really know about our favorite cosmeceutical ingredients?","volume":"3","author":"Levin J","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"issue":"2","key":"e_1_2_12_26_1","first-page":"18","article-title":"Acne vulgaris and the epidermal barrier: is acne vulgaris associated with inherent epidermal abnormalities that cause impairment of barrier functions? Do any topical acne therapies alter the structural and\/or functional integrity of the epidermal barrier?","volume":"6","author":"Thiboutot D","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.199581"},{"issue":"7","key":"e_1_2_12_28_1","first-page":"33","article-title":"Skin surface pH in acne vulgaris: insights from an observational study and review of the literature","volume":"10","author":"Prakash C","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_12_29_1","first-page":"86","article-title":"Skin pH in the elderly and appropriate skin care","volume":"2","author":"Schreml S","year":"2014","journal-title":"Eur Med J Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16212","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16212","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:36:44Z","timestamp":1777685804000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/jocd.16212"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16212","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}