{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:17:05Z","timestamp":1777933025946,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is an autoimmune disease which has an effect on the joints and skin. Tumor Necrosis Factor\u2010Like Weak Inducer of Apoptosis (TWEAK) is a multi\u2010functional cytokine which regulates the cellular processes and has been related to a variation of conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To measure the level of serum TWEAK in psoriatic diseased persons and its relationship to the PASI score pre\u2010 and post\u2010therapy with narrowband ultraviolet B phototherapy (NB\u2010UVB) and methotrexate (MTX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized controlled trial was conducted on 40 patients and 20 healthy persons as controls. Patient Group was randomly subdivided to two groups. The 1st group consisted of 20 patients who received NB\u2010UVB treatment. The 2nd group included 20 MTX\u2010treated candidates. Blood samples were drawn from patients in order to detect serum TWEAK levels using ELISA. The research was registered on Clinical Trials Registration: RCT approval numbers: NCT0481191.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean PASI score percent improvement after 12\u2009weeks of treatment was higher in the MTX group (90%) than NB\u2010UVB group (60%). The serum TWEAK level at baseline was 60.47\u2009\u00b1\u200912.6\u2009pg\/mL in NB\u2010UVB group and 54.69\u2009\u00b1\u200921.7\u2009pg\/mL in MTX group which reduced to 24.93\u2009\u00b1\u200917.6\u2009pg\/mL and 32.13\u2009\u00b1\u200923.6\u2009pg\/mL, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), after 12\u2009weeks of treatment. There was a positive correlation between the serum levels of TWEAK and severity of PASI score (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.399,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TWEAK grades in psoriasis are substantially higher than in controls. TWEAK levels were dramatically reduced during NB\u2010UVB and MTX treatment. TWEAK may have a potential sign for psoriasis diagnosis and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16215","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T05:10:06Z","timestamp":1706764206000},"page":"1905-1911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["TWEAK levels in psoriatic patients treated with narrowband ultraviolet B and methotrexate"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8638-0427","authenticated-orcid":false,"given":"Eisa Mohamed","family":"Hegazy","sequence":"first","affiliation":[{"name":"Dermatology, Venereology, and Andrology Department, Faculty of Medicine South Valley University  Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6349-1164","authenticated-orcid":false,"given":"Moustafa A.","family":"El\u00a0Taieb","sequence":"additional","affiliation":[{"name":"Dermatology, Venerology, and Andrology Department, Faculty of Medicine Aswan University  Aswan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassan Mohamed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology, and Andrology Department, Faculty of Medicine South Valley University  Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u2010Hassan M.","family":"Rageh","sequence":"additional","affiliation":[{"name":"Dermatology, Venerology, and Andrology Department, Faculty of Medicine Aswan University  Aswan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nour Mohammed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine Aswan University  Aswan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed K.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Medicine Assiut University  Asyut Jordan"},{"name":"Basic Medical Science Department, Faculty of Medicine Aqaba Medical Sciences University  Aqaba Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mohamed","family":"Younis","sequence":"additional","affiliation":[{"name":"Dermatology, Venerology, and Andrology Department, Faculty of Medicine Aswan University  Aswan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Ahmed","family":"Ali","sequence":"additional","affiliation":[{"name":"Dermatology, Venerology, and Andrology Department, Faculty of Medicine Aswan University  Aswan Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2015.10.004"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155391"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6746870"},{"issue":"9","key":"e_1_2_16_6_1","first-page":"626","article-title":"Psoriasis","volume":"87","author":"Weigle N","year":"2013","journal-title":"Am Fam 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