{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:03Z","timestamp":1747186383235,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Photothermolysis effect, resulting from laser procedures, can cause redness\/erythema, skin irritation and burning sensation, these symptoms may persist more than several days after the procedure and leading to discomfort for patients. Proper management is necessary for the better outcome, especially in early period after the laser procedure. Laminin\u20105 fragment contained soothing cream (CEBELIA Extreme Care\u00ae), is believed to have the calming\/soothing effect on overheated\/irritated skin after undergoing the laser treatment. It is assumed that cream can help alleviate the redness, erythema and burning sensation commonly experienced after laser treatments.<\/jats:p><jats:p>This study aimed to assess the effectiveness and safety of Laminin\u20105 fragment contained soothing cream (CEBELIA Extreme Care\u00ae) during the early post\u2010laser care period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This prospective split\u2010face study involved 28 patients who underwent CO<jats:sub>2<\/jats:sub> laser procedures and met inclusion criteria. The laser treatment was performed on both sides of the midface, and subsequently, the Laminin\u20105 fragment contained soothing cream (CEBELIA Extreme Care\u00ae) was applied to one side of the midface.<\/jats:p><jats:p>The efficacy of the cream was evaluated through objective measures, including photographic evaluation by two independent evaluators and assessment using an automatic skin analysis device. Subjective evaluations were also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The objective evaluation, based on the erythema score, revealed a statistical significant difference (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) between the side treated with Laminin\u20105 fragment contained soothing cream (CEBELIA Extreme Care\u00ae) and the control side. The erythema score was 1.34\u2009\u00b1\u20092.469 after the laser treatment with subsequent application of the cream for 10\u2009min and 0.7\u2009\u00b1\u20092.28 on the second day after the procedure. The subjective evaluation showed a statistically significant high of patient satisfaction. No complications were observed during the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of Laminin\u20105 fragment contained soothing cream (CEBELIA Extreme Care\u00ae) after the CO<jats:sub>2<\/jats:sub> laser treatment was found to be effective, particularly when applied for 10\u2009min after the laser treatment and on the second day after the procedure. Both objective and subjective evaluations yielded significantly different results. Patients reported a high satisfaction rate with the characteristics of the cream during the follow\u2010up period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16222","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:15:47Z","timestamp":1708427747000},"page":"2084-2089","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A prospective clinical study evaluating the efficacy and safety of a Laminin\u20105 fragment contained soothing cream in post\u2010laser treatment care"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2493-5279","authenticated-orcid":false,"given":"Galina","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Gyu","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yean Su","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine  Bucheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.14730\/aaps.2021.00143"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.09.009"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329414"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X10386930"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-016-0767-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2004.08.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.854625"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515965"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13533"},{"issue":"7","key":"e_1_2_11_11_1","first-page":"6","article-title":"Ablative laser resurfacing\u2014postoperative care","volume":"9","author":"Batra RS","year":"2004","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20254"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.738820"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2241745"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:21:33Z","timestamp":1716045693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,20]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jocd.16222"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16222","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2024,2,20]]},"assertion":[{"value":"2023-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}