{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:17:02Z","timestamp":1787959022516,"version":"build-2784847793"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To increase skin permeability, various transdermal delivery techniques have been developed. However, due to the stratum corneum as a skin barrier, transdermal delivery remains limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we evaluated efficacy and safety of arc\u2010poration as a novel technique disrupting the stratum corneum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Optical images and histological analysis using reconstituted human skin and porcine skin showed that the treatment of arc\u2010poration created micropores with an average diameter of approximately 100\u2009\u03bcm only to the depth of the stratum corneum, but not viable epidermis. In addition, the Franz diffusion cell experiment using reconstituted human skin showed a remarkable increase in permeability following pretreatment with arc\u2010poration. Clinical results clearly demonstrated the enhancement of the skin\u2010improving effect of cosmetics by pretreatment of arc\u2010poration in terms of gloss, hydration, flakiness, texture, tone, tone evenness, and pigmentation of skin, without causing abnormal skin responses. The concentration of ozone and nitrogen oxides generated by arc\u2010poration was below the permissible value for the human body.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Arc\u2010poration can increase skin permeability by creating stratum corneum\u2010specific micropores, which can enhance the skin\u2010improving effect of cosmetics without adverse responses.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16225","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:17:34Z","timestamp":1708427854000},"page":"2240-2248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Arc\u2010poration improves transdermal delivery of biomolecules"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5874-6831","authenticated-orcid":false,"given":"Sewoon","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Sensor Technology, Easytem Co., Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Ho","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Sensor Technology, Easytem Co., Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Sensor Technology, Easytem Co., Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoy Gun","family":"Kim","sequence":"additional","affiliation":[{"name":"Institute of Sensor Technology, Easytem Co., Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongho","family":"Lee","sequence":"additional","affiliation":[{"name":"APR Co., Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dasom","family":"Shin","sequence":"additional","affiliation":[{"name":"APR Co., Ltd.  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eok\u2010Soo","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Ewha Womans University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Woo","family":"Shin","sequence":"additional","affiliation":[{"name":"Institute of Sensor Technology, Easytem Co., Ltd.  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