{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:52:20Z","timestamp":1785804740986,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Prolonged use of medical masks has increased skin\u2010related issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the efficacy of a facial cream and facial mask in mitigating medical mask related skin symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy women were randomly assigned to apply a facial cream (<jats:italic>n<\/jats:italic>\u2009=\u200932) or a facial mask plus a facial cream (<jats:italic>n<\/jats:italic>\u2009=\u200932) on half\u2010faces after wearing medical masks for 4\u2009h (T<jats:sub>b<\/jats:sub>). Transepidermal water loss (TEWL), dryness score, and redness area were assessed at T<jats:sub>b<\/jats:sub> and 10\u2009min after using the cream (T<jats:sub>1<\/jats:sub>) in the facial cream group, and at T<jats:sub>b<\/jats:sub>, 1\u2009h after using the facial mask (T<jats:sub>2<\/jats:sub>), and 10\u2009min after using the cream (T<jats:sub>3<\/jats:sub>) in the combined use group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the facial cream group, the treated half\u2010face showed significantly better improvements from T<jats:sub>b<\/jats:sub> to T<jats:sub>1<\/jats:sub> in TEWL (\u22122.95\u2009\u00b1\u20090.38 vs. \u22120.68\u2009\u00b1\u20090.35\u2009g\/h\u00b7cm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and skin dryness score (\u22121.00\u2009\u00b1\u20090.12 vs. 0.00\u2009\u00b1\u20090.00, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In the combined use group, the treated half\u2010face showed significantly better improvements from T<jats:sub>b<\/jats:sub> to T<jats:sub>2<\/jats:sub> and T<jats:sub>3<\/jats:sub> in TEWL (T<jats:sub>2<\/jats:sub>, \u22123.46\u2009\u00b1\u20090.33 vs. \u22120.09\u2009\u00b1\u20090.13\u2009g\/h\u00b7cm<jats:sup>2<\/jats:sup>; T<jats:sub>3<\/jats:sub>, \u22124.67\u2009\u00b1\u20090.31 vs. \u22120.28\u2009\u00b1\u20090.22\u2009g\/h\u00b7cm<jats:sup>2<\/jats:sup>) and skin dryness score (T<jats:sub>2<\/jats:sub>, \u22120.63\u2009\u00b1\u20090.13 vs. 0.03\u2009\u00b1\u20090.03; T<jats:sub>3<\/jats:sub>, \u22120.94\u2009\u00b1\u20090.17 vs. 0.19\u2009\u00b1\u20090.07) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) then the untreated half\u2010face. The combined use group had significantly lower TEWL at T<jats:sub>3<\/jats:sub> than T<jats:sub>2<\/jats:sub> (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The reduction in redness area was similar between the treated and untreated half\u2010faces in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The test facial cream and mask significantly improved skin barrier function and alleviated dryness symptoms associated with medical mask use, with the combined use offering superior benefits.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16226","type":"journal-article","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T06:40:15Z","timestamp":1708756815000},"page":"2097-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of a moisturizing cream and facial mask for alleviating skin problems associated with medical mask use: A half\u2010face, randomized controlled study"],"prefix":"10.1111","volume":"23","author":[{"given":"Yang","family":"Wang","sequence":"first","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Niu","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengda","family":"Ye","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"He","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labatut","family":"Frederique","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al France  Chevilly\u2010Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"L'Oreal Dermatological Beauty L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kungchi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinrong","family":"Lin","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steel","family":"Andrew","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"L'Oreal Dermatological Beauty L'Or\u00e9al China  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flament","family":"Frederic","sequence":"additional","affiliation":[{"name":"Research and Innovation Center L'Or\u00e9al France  Chevilly\u2010Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[{"name":"Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"381","article-title":"Prevention and care of facial skin disorders caused by equipment protecting from COVID\u201019","volume":"49","author":"Bing W","year":"2020","journal-title":"J Clin 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