{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:33:03Z","timestamp":1747186383528,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment of vitiligo is still a big challenge for dermatologists. The efficacy of statins in the treatment of vitiligo is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim and Objective<\/jats:title><jats:p>We studied possible therapeutic effect of topical 1% niosomal atorvastatin ointment combined with topical 0.1% tacrolimus in treatment of non\u2010segmental vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a triple blind, pilot, randomized placebo\u2010controlled trial (RCT) that was performed in dermatology clinic. All the patients used topical 0.1% tacrolimus cream twice daily (BD). Moreover, the intervention group participants used topical 1% niosomal atorvastatin ointment, and control group participants were prescribed placebo ointment, BD. Patients were evaluated using vitiligo area surface index (VASI) score and patients' satisfaction at baseline and after 3\u2009months treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean patient satisfaction in the intervention and control groups were 5\u2009\u00b1\u20091.4 and 3.5\u2009\u00b1\u20091.9; the difference between groups was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.9). We found statistically significant difference in VASI score before and after treatment in both intervention and control groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.01 and <jats:italic>p<\/jats:italic>\u2009=\u20090.03, respectively). However, comparison of the VASI score between groups was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u20090.62). We also found no significant correlation between VASI score and other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The result of this study indicates that adding of niosomal atorvastatin 1% ointment to topical calcineurin inhibitor has no additional effect on non\u2010segmental type of vitiligo. Further large studies with different combinations are recommended before any conclusive result can be concluded on efficacy of statins in vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16227","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T10:05:27Z","timestamp":1707818727000},"page":"2103-2108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing effectiveness of adding niosomal atorvastatin 1% ointment to topical calcineurin inhibitor treatment in non\u2010segmental vitiligo"],"prefix":"10.1111","volume":"23","author":[{"given":"Hamed","family":"Zartab","sequence":"first","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"},{"name":"Taleghani Hospital Urmia University of Medical Sciences  Urmia 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Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Firooz","sequence":"additional","affiliation":[{"name":"Center for Research and Training in Skin Diseases and Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rezvan","family":"Amiri","sequence":"additional","affiliation":[{"name":"Leishmaniasis Research Center Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"105","article-title":"Epidemiological aspects and disease association of childhood vitiligo","volume":"25","author":"Farajzadeh S","year":"2015","journal-title":"J Pakistan Assoc 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