{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T12:47:47Z","timestamp":1781700467380,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperbaric oxygen therapy (HBOT) involves patients breathing 100% oxygen in a pressurized chamber, above 1 atmosphere. Many centers are now promoting the use of HBOT for skin rejuvenation. However, the current indications for HBOT do not encompass aesthetic applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this evidence\u2010based review was to assess the existing literature regarding the utilization of HBOT in medical aesthetics and rejuvenation, evaluate its effectiveness and safety, and conduct a cost analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>PubMed Interface, Cochrane Library, Google Scholar, and Embase searches were carried out. The Best Bets methodology was used, and the risk of bias was appraised using the Quality Assessment Tool for Quantitative Studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Main Findings<\/jats:title><jats:p>This review included a total of 17 human studies with a total of 766 participants. Three studies were classified as level II evidence, three studies were of level III evidence, and 11 were of level IV evidence. All the included studies were judged at high risk of bias. The most relevant findings supported by level II evidence were that HBOT decreased the shedding rate post\u2010FUE hair transplant (27.6\u2009\u00b1\u20092.6% vs. 69.1\u2009\u00b1\u20092.4%) but this did not affect the final outcome between HBOT (96.9\u2009\u00b1\u20090.5%) and the control (93.8\u2009\u00b1\u20090.6%). Moreover, level III evidence demonstrated that following HBOT, there was a significant increase in elastic fiber length (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.0001, effect size\u2009=\u20092.71) and a significant decrease in fiber fragmentation (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). There was also a significant increase in collagen fiber density following HBOT (<jats:italic>p<\/jats:italic>\u2009=\u20090.0001, effect size\u2009=\u20091.10). However, there was no significant effect of antioxidant vitamins A, C, and E with HBOT. The inflammatory response significantly decreased after 7\u2009days of HBOT with a decreased expression of IL\u201012p40, MIP\u20101\u03b2, and PDGF\u2010BB and a higher expression of IL\u20101Ra. Moreover, HBOT was used prophylactically prior to abdominoplasty to decrease the risk of complications. In this study, complications were decreased from 32.6% (89 patients) to 8.4% (7 patients) with a <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and in a multivariate analysis, preoperative HBOT was an independent protective factor against postoperative complications (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Recommendations<\/jats:title><jats:p>There is conflicting evidence on how the method of action of HBOT can have a beneficiary effect in aesthetic and whether the treatment is justifiable. To our knowledge, this is the first comprehensive review discussing the available evidence regarding the use of HBOT in many aesthetic clinical scenarios, including preventive, medical, and surgical settings. However, randomized clinical trials with longer follow\u2010up and better patient selection are needed to be able to generate a reliable conclusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16228","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T08:49:29Z","timestamp":1707986969000},"page":"1940-1955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The role, safety, and efficacy of hyperbaric oxygen therapy in aesthetic practice\u2014An evidence\u2010based review"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-8725","authenticated-orcid":false,"given":"Juanita","family":"Parnis","sequence":"first","affiliation":[{"name":"Academic Plastic Surgery Programmes, Centre for Cell Biology &amp; Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"},{"name":"Plastic Surgery and Burns Unit Mater Dei Hospital  Msida Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1336-6553","authenticated-orcid":false,"given":"Anna Maria Fenech","family":"Magrin","sequence":"additional","affiliation":[{"name":"Academic Plastic Surgery Programmes, Centre for Cell Biology &amp; Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8192-9916","authenticated-orcid":false,"given":"Haidar","family":"Hassan","sequence":"additional","affiliation":[{"name":"Academic Plastic Surgery Programmes, Centre for Cell Biology &amp; Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfaci.6.1.31"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"257","article-title":"Hyperbaric oxygen therapy in plastic surgery practice: case series and literature overview","volume":"40","author":"Bassetto F","year":"2019","journal-title":"G Chir"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2020.4728"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007029"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003136"},{"key":"e_1_2_9_7_1","unstructured":"Undersea & Hyperbaric Medical Society Blog (UHMSblog) 2023. Accessed December 8 2023.https:\/\/uhmsblog.wordpress.com\/"},{"issue":"1","key":"e_1_2_9_8_1","first-page":"24","article-title":"Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non\u2010accepted clinical indications and practice of hyperbaric oxygen treatment","volume":"47","author":"Mathieu D","year":"2017","journal-title":"Diving Hyperb Med"},{"key":"e_1_2_9_9_1","unstructured":"BestBETs \u2010 Best Evidence Topics (BETs) Introduction 2023. Cited 2023 6 July.https:\/\/bestbets.org\/home\/bets\u2010introduction.php"},{"key":"e_1_2_9_10_1","unstructured":"Quality Assessment Tool for Quantitative Studies;2023. Cited 2023 9 July.https:\/\/www.ephpp.ca\/quality\u2010assessment\u2010tool\u2010for\u2010quantitative\u2010studies\/."},{"key":"e_1_2_9_11_1","unstructured":"OCEBM Levels of Evidence Working Group*.\u201cThe Oxford 2011 Levels of Evidence\u201d. Oxford Centre for Evidence\u2010based Medicine. Accessed December 8 2023.http:\/\/www.cebm.net\/index.aspx?o=5653*OCEBM Table of Evidence Working Group = Jeremy Howick Iain Chalmers (James Lind Library) Paul Glasziou Trish Greenhalgh Carl Heneghan Alessandro Liberati Ivan Moschetti Bob Phillips Hazel Thornton Olive Goddard and Mary Hodgkinson2011."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203701"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(99)00034-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019857"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002417"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13665"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-4-7"},{"issue":"1","key":"e_1_2_9_18_1","article-title":"Successful hyperbaric oxygen therapy in complications of fillers rhinoplasty\u2010cases report","volume":"9","author":"Tsai M\u2010C","year":"2014","journal-title":"Int J Alternative Med"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001618"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2019.00059"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.31486\/toj.18.0133"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13611"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000002624"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S344408"},{"key":"e_1_2_9_25_1","first-page":"e61","article-title":"Role of hyperbaric oxygen therapy in cosmetic and reconstructive surgery in ischemic soft tissue wounds: a case series","volume":"22","author":"Simman R","year":"2022","journal-title":"Eplasty"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000005180"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-017-0949-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1800132"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-022-02783-0"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102725"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1972.tb05080.x"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-012-0362-2"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:21:55Z","timestamp":1716045715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jocd.16228"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16228","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,15]]},"assertion":[{"value":"2023-11-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}