{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T09:28:30Z","timestamp":1784971710819,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011915","name":"Taylor\u2019s University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite the demonstrated anti\u2010melanogenic and UV protective effects of Zerumbone (ZER) in\u00a0vitro, there is a lack of clinical trials that have been done to assess these properties. The primary objective of this study was to assess the effectiveness of ZER in lightening the skin tone of human participants with a single\u2010blind approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010six participants were randomly assigned to two groups to investigate the application location (left or right volar forearm) for the placebo and ZER creams. Both creams were topically administered to the volar forearms twice daily over a duration of 4\u2009weeks. Initial skin irritation was assessed before and 30\u2009min after applying creams. The melanin and erythema levels were quantified with Mexameter MX 18.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty participants were included in the analysis. The cream formulation had excellent physical properties and was well\u2010received by the participants. The initial skin irritation study results indicated that neither of the creams elicited an allergic reaction. The administration of ZER cream resulted in a statistically significant reduction in melanin levels (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) after 1\u2009week compared to the initial baseline. Furthermore, after 2\u2009weeks of application, ZER cream demonstrated significant differences in melanin levels compared to placebo (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). No adverse effects were observed in the group using ZER cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ZER demonstrated significant potential as a skin\u2010lightening agent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16234","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T08:04:01Z","timestamp":1708157041000},"page":"2117-2124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Skin lightening properties of zerumbone cream: A placebo\u2010controlled study"],"prefix":"10.1111","volume":"23","author":[{"given":"Wee Nie","family":"Kuek","sequence":"first","affiliation":[{"name":"School of Pharmacy, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi Ru","family":"Tiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Yin","family":"Yow","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Life Sciences, Faculty of Health and Medical Sciences University Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li Kar Stella","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Faculty of Health and Medical Sciences Taylor's University  Subang Jaya Malaysia"},{"name":"Digital Health and Medical Advancements Impact Lab Taylor's University  Subang Jaya Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Wun","family":"How","sequence":"additional","affiliation":[{"name":"School of Pharmacy Monash University Malaysia  Bandar Sunway Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi Hao Daniel","family":"Looi","sequence":"additional","affiliation":[{"name":"CytoHealth Centre of Research Sdn. 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