{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:45:56Z","timestamp":1793378756743,"version":"4.5.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common inflammatory disease associated with various sequelae after skin lesion remission. Acne erythema has been considered simple erythema or a vascular lesion; however, because the understanding of this disease has improved, acne erythema is currently considered an early scar with erythematous components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study evaluated the efficacy of using both a 595\u2010nm pulsed dye laser (PDL) and 1565\u2010nm nonablative fractional laser (NAFL) for the treatment of erythematous scars caused by acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety patients with acne scars were equally randomized to two groups. Group A (<jats:italic>n<\/jats:italic>\u2009=\u200945) received treatment with the NAFL. Group B (<jats:italic>n<\/jats:italic>\u2009=\u200945) received treatment with the PDL and NAFL. Each patient underwent one treatment session and 4\u2009weeks of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Qualitative (\u03c7<jats:sup>2<\/jats:sup>\u2009=\u200912.415; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and quantitative (<jats:italic>t<\/jats:italic>\u2009=\u20092.675; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) scores of Groups A and B were determined using a global scarring grading system and exhibited statistically significant differences. The quantitative score of Group A was higher than that of Group B (6.67\u2009\u00b1\u20093.46 vs. 4.98\u2009\u00b1\u20092.44). The erythema areas of the groups differed significantly after treatment, with Group B exhibiting more notable score improvements (5.00 [3.10, 7.10] vs. 2.80 [1.65, 4.60]; <jats:italic>Z<\/jats:italic>\u2009=\u20093.072; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The erythema regression rate of Group B (88.9%) was significantly higher than that of Group A (66.7%) (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200920.295; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Adverse events, including redness and swelling (86.6%), scabbing (78.8%), and purpura (36.6%), occurred within 7\u2009days for 86.6% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined use of the PDL and NAFL is safe and effective for erythematous acne scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16235","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T10:26:02Z","timestamp":1709288762000},"page":"2015-2021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Treatment of erythematous acne scars using 595\u2010nm pulsed dye laser combined with 1565\u2010nm <scp>ResurFX<\/scp> nonablative fractional laser"],"prefix":"10.1111","volume":"23","author":[{"given":"Chenxi","family":"Zhou","sequence":"first","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'An Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Yao","sequence":"additional","affiliation":[{"name":"DEYUE Clinc, DE YI Skin  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Chen","sequence":"additional","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'An Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'An Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Zhang","sequence":"additional","affiliation":[{"name":"DEYUE Clinc, DE YI Skin  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Chen","sequence":"additional","affiliation":[{"name":"DEYUE Clinc, DE YI Skin  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"DEXI Clinc, DE YI Skin  Xi'An Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Qin","sequence":"additional","affiliation":[{"name":"DEYUE Clinc, DE YI Skin  Shenzhen China"},{"name":"Peking University Shenzhen Hospital  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12134388"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.854626"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23484"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14741"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000006983"},{"issue":"12","key":"e_1_2_9_7_1","first-page":"1458","article-title":"Postacne scarring: a qualitative global scarring grading system","volume":"32","author":"Goodman GJ","year":"2006","journal-title":"Dermatologic Surg"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2006.00222.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33180.x"},{"issue":"13","key":"e_1_2_9_10_1","first-page":"235","article-title":"Acne scar treatment: a multimodality approach tailored to scar type","volume":"42","author":"Zaleski\u2010Larsen LA","year":"2016","journal-title":"Dermatologic Surg"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13832"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0358-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1773383"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12924"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T15:20:22Z","timestamp":1716045622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jocd.16235"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16235","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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