{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:43:42Z","timestamp":1790286222187,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Salicylic acid (SA) has been used for treatment of acne of different severity levels. However, there are few researches about the safety and efficacy for treatment of mild to moderate acne, and the improvement of the skin condition by using 2% supramolecular salicylic acid (SSA) compared to Davuwen Adapaline gel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A multicenter, randomized, assessor\u2010blind and parallel\u2010controlled study was conducted. A total of 500 patients (trial group: 249, control group: 251) with mild to moderate (grade I\u2013II) facial acne vulgaris were recruited in this study over a 16\u2010week trial period. Patients in the trial group were treated with Broda 2% SSA hydrogel, while control group treated with Davuwen Adapaline gel once a day. The number of inflammatory papules, comedones, and pustules were counted and the rate of lesion reduction was calculated pre\u2010 and post\u2010treatment. Then, the skin physiological indicators, including L*a*b*, TEWL, skin sebum and hydration were measured. Statistical analysis was conducted using SAS 9.4. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the end of 12\u2009weeks' therapy, the regression and markedly improvement rate of the trail group and the control group were 51.01% and 43.10% respectively, and there was no significant difference in the improvement rate between two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0831). Although, there was no difference in adverse events rate between two groups, the adverse events rate of the trail group was 0.40%, a little lower than the control group (0.80%). Moreover, there was a significant difference in the numbers of pores at T1 between two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both 2% SSA and Adapaline gel were equally effective in the treatment of mild to moderate acne vulgaris. 2% SSA is worth the clinical promotion and application in mild to moderate acne vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16238","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T01:41:48Z","timestamp":1712626908000},"page":"2125-2134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["2% supramolecular salicylic acid hydrogel vs. adapaline gel in mild to moderate acne vulgaris treatment: A multicenter, randomized, evaluator\u2010blind, parallel\u2010controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6650-7651","authenticated-orcid":false,"given":"Cong Xiu","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JinLing","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-8564","authenticated-orcid":false,"given":"Xinghua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Hospital of China Medical University  Shenyang City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5109-6055","authenticated-orcid":false,"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, West China Hospital Sichuan University  Chengdu City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology General Hospital of Ningxia Medical University  Yinchuan City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leihong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Huashan Hospital affiliated to Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Dermatology the Second Affiliated Hospital of Xi'an Jiaotong University  Xincheng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xiangya Hospital Central South University  Changsha City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhong","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, PLA Air Force General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1847-2375","authenticated-orcid":false,"given":"Yue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Department of Dermatology, NanFang Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010venereology The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61729-2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1164"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.14788"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2018.1518329"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20200211-01"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14881"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175273"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00844-5"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27010216"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S397541"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16010087"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13934"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251167"},{"key":"e_1_2_11_17_1","doi-asserted-by":"crossref","unstructured":"Calvisi L.J.J.o.c.d. Efficacy of a combined chemical peel and topical salicylic acid\u2010based gel combination in the treatment of active acne.2021: p.2\u20136.","DOI":"10.1111\/jocd.14281"},{"issue":"2","key":"e_1_2_11_18_1","first-page":"393","article-title":"Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild\u2010to\u2010moderate acne vulgaris","volume":"19","author":"Dayal S","year":"2020","journal-title":"Randomized Controlled Trial"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1103a63"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14948"},{"key":"e_1_2_11_21_1","first-page":"961","article-title":"Licochalcone a in combination with salicylic acid as fluid based and Hydroxy\u2010complex 10% cream for the treatment of mild acne: a multicenter prospective","volume":"12","author":"Dall'Oglio F","year":"2019","journal-title":"Trial"},{"issue":"4","key":"e_1_2_11_22_1","first-page":"442","article-title":"Combination superficial peels with salicylic acid and post\u2010Peel Retinoids","volume":"15","author":"Kligman DE","year":"2016","journal-title":"J. Drugs Dermatol."},{"issue":"5","key":"e_1_2_11_23_1","article-title":"Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha\u2010hydroxy acid) for acne","volume":"5","author":"Liu H","year":"2020","journal-title":"Cochrane Database Syst. Rev."}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,18]],"date-time":"2024-05-18T11:20:40Z","timestamp":1716031240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,8]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jocd.16238"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16238","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,8]]},"assertion":[{"value":"2023-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}