{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T01:49:17Z","timestamp":1769824157443,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,3]],"date-time":"2024-03-03T00:00:00Z","timestamp":1709424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Frontal fibrosing alopecia (FFA) is characterized by scarring alopecia of the frontotemporal scalp and facial papules. Isotretinoin is a vitamin A\u2010derived retinoid discovered in 1955 and approved for treating nodulocystic acne. This drug can also affect facial papules and frontotemporal hair loss in patients with FFA. In this article, we conducted a review of the available studies investigating the use of oral isotretinoin for FFA treatment. Our study provides insights into the efficacy and safety of isotretinoin as a potential treatment option for FFA and highlights areas for future research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, we aimed to investigate the potential advantages and disadvantages of isotretinoin as a treatment for FFA. To identify all relevant articles, we developed a comprehensive search strategy and conducted a thorough search of three major databases: PubMed, Embase, and Science Direct. We retrieved a total of 82 articles from the search results. Two independent reviewers then screened each of the 82 articles based on our inclusion and exclusion criteria, resulting in the identification of 15 articles that were deemed relevant to our study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Across the 15 articles, 232 patients who suffered from FFA were involved. Nearly 90% of patients experienced a significant reduction of symptoms after receiving oral isotretinoin at 10\u201340\u2009mg daily. We conclude that isotretinoin can positively affect facial papules and help suppress hair loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16245","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T04:39:40Z","timestamp":1709527180000},"page":"1956-1963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A review of isotretinoin in the treatment of frontal fibrosing alopecia"],"prefix":"10.1111","volume":"23","author":[{"given":"Amirhossein","family":"Shahpar","sequence":"first","affiliation":[{"name":"Gastrointestinal Research Center Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9159-3487","authenticated-orcid":false,"given":"Nazanin Zeinali","family":"Nezhad","sequence":"additional","affiliation":[{"name":"Physiology Research Center Institute of Neuropharmacology, Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akram\u2010Sadat","family":"Sahaf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3171-5933","authenticated-orcid":false,"given":"Najmeh","family":"Ahramiyanpour","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bushehr University of Medical Sciences Bushehr Iran"},{"name":"Pathology and Stem Cell Research Center Bushehr University of Medical Sciences Bushehr Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10091805"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.038"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1201a80"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12424"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.07.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10809.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00424-y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.07.035"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.26444\/aaem\/141324"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.11.012"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4233"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.774"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14670"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481695"},{"issue":"2","key":"e_1_2_8_16_1","first-page":"e21901","article-title":"Frontal Fibrosing Alopecia mimicking Alopecia Syphilitica","volume":"14","author":"Diehl KL","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12379"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2012.1873"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S235980"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615281"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12139"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09965.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.043"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01580.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12232"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.003"},{"issue":"8","key":"e_1_2_8_27_1","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/ddg.13601","article-title":"Frontal fibrosing alopecia\u2013review of recent case reports and case series in PubMed. JDDG","volume":"16","author":"Valesky EM","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.09.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.151243"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02152-4"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1750553"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.04.1118"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.01.030"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000464334"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2017.08.018"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14274"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13037"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2018.1542480"},{"issue":"10","key":"e_1_2_8_39_1","first-page":"988","article-title":"Efficacy of Isotretinoin and Acitretin in treatment of Frontal Fibrosing Alopecia: retrospective analysis of 54 cases","volume":"16","author":"Rakowska A","year":"2017","journal-title":"Journal of Drugs in Dermatology: JDD"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2020.03.003"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12633"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3210"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14730"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2012.00947.x"},{"issue":"4","key":"e_1_2_8_45_1","first-page":"5","article-title":"Holmes S. Frontal Fibrosing Alopecia","volume":"21","author":"Frontal HS","year":"2016","journal-title":"Skin Therapy Lett"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13785"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13071"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512039"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.11.003"},{"key":"e_1_2_8_50_1","first-page":"273","article-title":"Frontal fibrosing alopecia: efficacy of treatment modalities. International","volume":"11","author":"Gamret AC","year":"2019","journal-title":"J Women's Health"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/3856674"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15232"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00643-2"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.111"},{"issue":"5","key":"e_1_2_8_55_1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4103\/ijp.ijp_695_21","article-title":"Evaluation of peripheral lymphocyte subsets in acne vulgaris patients before and after systemic isotretinoin treatment","volume":"54","author":"Gunaydin SD","year":"2022","journal-title":"Indian J Pharm"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13251"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T19:01:11Z","timestamp":1731524471000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,3]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/jocd.16245"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16245","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,3]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}