{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:40:34Z","timestamp":1783698034222,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical antioxidants and retinoids are foundational components of an effective skincare regimen. Pyrroloquinoline quinone (PQQ) is a potent free radical scavenger that supports efficient mitochondrial energy creation. An advanced antioxidant combines topical allyl PQQ with existing WEL antioxidant technology (TAP) to comprehensively address extrinsic and intrinsic skin aging. In conjunction with TAP, a double\u2010conjugated retinoid\/alpha hydroxy acid (AHA\u2010Ret) designed to minimize irritation and optimize delivery was used over 12\u2009weeks to improve the appearance of photodamaged skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Twice\u2010daily application of TAP and nightly application of AHA\u2010Ret was evaluated in female participants aged 40\u201365\u2009years with FST IV\u2013V and mild (3) to moderate (6) facial photodamage using a 10\u2010point grading scale. Visible improvements from baseline in lines\/wrinkles, skin texture, skin tone, skin dullness and erythema were assessed using a six\u2010point grading scale (0\u2009=\u2009None to 5\u2009=\u2009Severe). Adverse Events (AEs) were captured throughout the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants (<jats:italic>N<\/jats:italic>\u2009=\u200921; mean age, 56\u2009years) equally represented mild and moderate photodamage, and FST IV and V (41%, Hispanic; 36%, African American; and 32%, Caucasian). Significant mean improvements from baseline occurred in skin dullness, skin texture, and skin tone (all, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and significant mean reductions from baseline were demonstrated in erythema and melanin at Week 12. Mild, transient AEs were reported. No participant discontinued study participation due to an AE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A skincare regimen comprised of an advanced antioxidant and AHA\u2010Ret cream, in conjunction with daily use of a broad\u2010spectrum sunscreen (SPF 56), led to significant improvements at 12\u2009weeks in the appearance of photodamaged skin in females with FST IV and V.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16246","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T10:33:44Z","timestamp":1708943624000},"page":"1291-1297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of an advanced antioxidant and double\u2010conjugated retinoid\/<scp>AHA<\/scp> cream in participants with <scp>FST IV\u2013V<\/scp>"],"prefix":"10.1111","volume":"23","author":[{"given":"Pearl E.","family":"Grimes","sequence":"first","affiliation":[{"name":"Grimes Center of Medical and Aesthetic Dermatology Vitiligo &amp; Pigmentation Institute of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-1574","authenticated-orcid":false,"given":"Diane B.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Clinical, Medical &amp; Scientific Affairs skinbetter science, a Dermatological Beauty brand of L'Or\u00e9al USA  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","first-page":"s121","article-title":"Photoaging and photoprotection in United States Hispanic population","volume":"18","author":"Zheng Q","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.081"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"31","article-title":"Aging differences in ethnic skin","volume":"9","author":"Vashi NA","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"issue":"6","key":"e_1_2_11_5_1","first-page":"695","article-title":"Revisiting the skin health and beauty pyramid: a clinically based guide to selecting topical skincare products","volume":"20","author":"Draelos ZD","year":"2021","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/php.12375"},{"issue":"4","key":"e_1_2_11_7_1","first-page":"414","article-title":"The skin health and beauty pyramid: a clinically based guide to selecting topical skincare products","volume":"13","author":"Mayoral FA","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00408.x"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"219","article-title":"Studies on free radicals, antioxidants, and co\u2010factors","volume":"2","author":"Rahman K","year":"2007","journal-title":"Clin Interv Aging"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12484"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1224259"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology8020029"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"46","article-title":"Evaluation of the antioxidant capacity and protective effects of a comprehensive topical antioxidant containing water\u2010soluble, enzymatic, and lipid\u2010soluble antioxidants","volume":"12","author":"McDaniel DH","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-020-02083-0"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13991"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.030130"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11101441"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12381"},{"issue":"7","key":"e_1_2_11_19_1","first-page":"709","article-title":"Skin of color skin care needs: results of a multi\u2010center\u2010based survey","volume":"21","author":"Geisler A","year":"2022","journal-title":"J Drugs Dermatol"},{"issue":"9","key":"e_1_2_11_20_1","first-page":"858","article-title":"Understanding the female African American facial aesthetic patient","volume":"18","author":"Alexis A","year":"2019","journal-title":"J Drugs Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16246","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T03:12:37Z","timestamp":1711595557000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/jocd.16246"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16246","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}