{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:19:24Z","timestamp":1781806764087,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Vitiligo is a skin pigmentation disorder caused by the selective degradation of melanocytes. This study investigates the therapeutic effects of microneedling with and without N\u2010acetylcysteine (NAC) in patients with persistent and limited vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This research employed a clinical trial design with double\u2010blind randomization. Individuals affected by vitiligo and seeking treatment at Rasool Akram Medical Complex were divided into two separate treatment groups. In the intervention group, 24 affected areas underwent meso\u2010microneedling using 5% NAC ampoules over six sessions, in addition to the application of 4.7% NAC cream once daily on the specified area. Conversely, the control group, consisting of 22 lesions, underwent microneedling using distilled water during six sessions. The severity of lesions and the extent of repigmentation were gauged using the Modified VETI Score. Assessment of treatment efficacy was determined through both physician evaluations and patient feedback.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty patients with a mean age of 36.4\u2009years were recruited. The mean percentage of lesions and their intensity were significantly improved 2\u2009weeks after the third session and 1\u2009month after the end of the treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). There was no statistically significant difference between the intervention and control groups. Gender, age, family history, duration of disease, duration of disease stability, and history of hypothyroidism had no statistically significant relationship with patients' treatment outcomes (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Microneedling with or without the application of NAC appears to be an effective treatment option for persistent vitiligo lesions. However, despite the higher improvement rate with the application of NAC, the difference was not significant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16274","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T12:22:25Z","timestamp":1710246145000},"page":"2220-2230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of efficacy and safety of vitiligo treatment with micro\u2010needling combined with <scp>N\u2010Acetylcysteine<\/scp> and micro\u2010needling alone: A double\u2010blinded randomized controlled clinical trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Najmolsadat","family":"Atefi","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences  Tehran 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