{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:17:38Z","timestamp":1790014658183,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Q\u2010switched (QS) Nd: YAG laser is one of the treatment options for solar lentigines (SLs). However, the incidence of post\u2010inflammatory hyperpigmentation (PIH) is a common complication, especially in dark\u2010complexioned skin. Isobutylamido thiazolyl resorcinol (ITR) has been reported as a preventive modality for ultraviolet B (UVB)\u2010induced hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aims to evaluate the efficacy and safety of ITR for the prevention of laser\u2010induced PIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>A randomized, evaluator\u2010blinded study including 24 subjects with SLs was conducted. Three SLs of each patient were randomized into three groups, which were to apply ITR twice daily, once daily, and no application for 2\u2009weeks. Thereafter, 532\u2010nm QS Nd: YAG laser was performed. Incidence of laser\u2010induced PIH, relative melanin index (RMI), mean luminance score (L*), hyperpigmentation score, and adverse events were recorded for 2\u2009months post\u2010laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of PIH at the 4th week after laser treatment was significantly lower in the ITR twice\u2010daily group compared to the no\u2010application group (20.83% vs. 50%, <jats:italic>p<\/jats:italic>\u2009=\u20090.028). There was no statistically significant difference in RMI, mean L*, and hyperpigmentation score between treatments at all visits. No serious adverse events were reported regarding ITR application and laser treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Two\u2010week application of ITR prior to QS: Nd YAG laser treatment may potentially reduce the incidence of PIH. A longer duration of application, including after the laser procedure, may be more beneficial for the prevention of laser\u2010induced PIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16287","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T09:58:40Z","timestamp":1710755920000},"page":"2450-2457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser\u2010induced post\u2010inflammatory hyperpigmentation: A\u00a0randomized, controlled trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-939X","authenticated-orcid":false,"given":"Vasanop","family":"Vachiramon","sequence":"first","affiliation":[{"name":"Division of Dermatology, Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok 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