{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:49:35Z","timestamp":1781002175949,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is one of the most common dermatological disorders. <jats:italic>Berberis integerrima<\/jats:italic> Bunge belongs to the Berberidaceae family. Several studies on different <jats:italic>Berberis<\/jats:italic> species in addition to <jats:italic>B. integerrima<\/jats:italic> have shown antimicrobial, antioxidant, and anti\u2010inflammatory effects. Spearmint essential oil also has antioxidant, antibacterial, and anti\u2010inflammatory activities. This study aimed to evaluate the clinical effectiveness of the topical combination of <jats:italic>B. integerrima<\/jats:italic> root extract and spearmint essential oil in the treatment of acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with mild to moderate facial acne who met the inclusion criteria were randomly assigned to either drug (<jats:italic>B. integerrima<\/jats:italic> extract\/spearmint essential oil topical solution) or control (clindamycin 1% topical solution) groups. Each group applied the solution twice a day for 4\u2009weeks. Before and at the end of the intervention, the number of lesions and mGAGS (Modified Global Acne Grading Scale) score were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients in each group of drug and control completed the study. Topical <jats:italic>B.integerrima<\/jats:italic> root extract\/spearmint essential oil significantly reduced the number of lesions (27.33\u2009\u00b1\u200926.17 vs. 21.58\u2009\u00b1\u200921.10; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and mGAGS (18.76\u2009\u00b1\u20098.61 vs. 13.87\u2009\u00b1\u20098.14; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) at the end of the intervention. However, there was no significant difference between the two groups regarding the number of lesions (<jats:italic>p<\/jats:italic>\u2009=\u20090.906) and mGAGS (<jats:italic>p<\/jats:italic>\u2009=\u20090.882).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>B. integerrima<\/jats:italic> root extract combined with spearmint essential oil has significant anti\u2010acne effects, comparable to topical antibiotic clindamycin. It could be considered as a potential treatment for acne vulgaris. However, more studies with larger sample sizes and longer durations are required to confirm this effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16291","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T08:44:50Z","timestamp":1711615490000},"page":"2458-2466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the effectiveness of <i>Berberis integerrima<\/i> Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6215-6818","authenticated-orcid":false,"given":"Sara","family":"Saeidi","sequence":"first","affiliation":[{"name":"Students Research Committee, School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Mustafa","family":"Ghanadian","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazila","family":"Poostiyan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasool","family":"Soltani","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Infectious Diseases and Tropical Medicine Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2021-8-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"48","article-title":"What's new in the management of acne vulgaris","volume":"104","author":"Kircik LH","year":"2019","journal-title":"Cutis"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101578"},{"issue":"8","key":"e_1_2_8_6_1","first-page":"475","article-title":"Acne vulgaris: diagnosis and treatment","volume":"100","author":"Oge' LK","year":"2019","journal-title":"Am Fam Physician"},{"issue":"7","key":"e_1_2_8_7_1","article-title":"Epidemiology of acne vulgaris and its association with lifestyle among adolescents and young adults in Hail, Kingdom of Saudi Arabia: a community\u2010based study","volume":"12","author":"Alshammrie FF","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2011.11.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/dtb.2023.000051"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.17633"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2056L"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15719"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1998.tb140250.x"},{"issue":"4","key":"e_1_2_8_14_1","first-page":"1313","article-title":"Antihyperglycemic and antihyperlipidemic effects of fruit aqueous extract of Berberis integerrima Bge. 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