{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:04:55Z","timestamp":1773666295115,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tetrahexydecyl ascorbate (THDA) is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone (AZ). Studies have shown that the topical application of THDA may have photoprotective effects. Similarly, AZ has been shown to mitigate oxidative and inflammatory stress, thereby improving the appearance of photoaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the effects of THDA and AZ (THDA\u2010AZ) on skin photoaging compared to THDA alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In this double\u2010blind, randomized controlled trial, healthy individuals aged 30 to 65 were included and 44 participants were randomized to receive either THDA\u2010AZ (THDA 5%\u2009+\u2009AZ 1%) or THDA only (THDA 5%) for 8\u2009weeks. Facial photographs were taken at 0, 4, and 8\u2009weeks to analyze wrinkle severity, pigment intensity, and redness intensity. A skin colorimeter was used to assess infraorbital pigmentation and erythema. Self\u2010perception of skin and tolerability were assessed through questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Average wrinkle severity was significantly decreased in the THDA\u2010AZ group at Weeks 4 and 8 by 0.75% (<jats:italic>p<\/jats:italic>\u2009=\u20090.023) and 3.72% (<jats:italic>p<\/jats:italic>\u2009=\u20090.048), respectively, compared to the THDA group where wrinkle severity at Weeks 4 and 8 was increased by 7.88% and 4.48%, respectively. Facial pigment intensity was significantly decreased in the THDA\u2010AZ group by 4.10% (<jats:italic>p<\/jats:italic>\u2009=\u20090.0002) at Week 8 compared to a 0.69% decrease in the THDA group. Facial redness intensity was decreased in the THDA\u2010AZ group at Weeks 4 and 8 by 3.73% (<jats:italic>p<\/jats:italic>\u2009=\u20090.0162) and 14.25% (<jats:italic>p<\/jats:italic>\u2009=\u20090.045), respectively, compared to the THDA group where at Weeks 4 and 8 erythema increased by 27.5% and 8.34%, respectively. There were no significant differences in either group for infraorbital pigmentation or erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Daily use of combined THDA and AZ may improve facial wrinkle severity, pigment intensity, and erythema to a greater extent than THDA. While THDA alone increases facial wrinkle severity and erythema, the addition of AZ reduces both.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16292","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T08:59:21Z","timestamp":1711357161000},"page":"2467-2477","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prospective randomized double\u2010blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging"],"prefix":"10.1111","volume":"23","author":[{"given":"Nasima","family":"Afzal","sequence":"first","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Integrative Skin Science and Research  Sacramento California 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