{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:41:42Z","timestamp":1785872502439,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The signs of aging seem to be more visible on the neck compared to other locations, especially if a patient has already gone through facial rejuvenation procedures. Treatment of the aging neck imposes a challenge to the clinician, since one single approach is usually not enough to achieve the desired result, requiring multiple injections and sessions, which apart from being painful for the patients, is time\u2010consuming for the clinician.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe the use of calcium hydroxyapatite, incobotulinum toxin type A and Cohesive poly\u2010densified matrix hyaluronic acid diluted in the same syringe and injected in the same session for neck rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Fifteen women, older than 18\u2009years, with cervical skin flaccidity grade 1\u20134 in a previously validated 5\u2010point rating scale (<jats:italic>Dermatologic Surg<\/jats:italic>, 2016; 42, S94), who sought neck rejuvenation were injected in this pilot study with a single session with a combined hybrid mixture of calcium hydroxyapatite, incobotulinum toxin type A, and Cohesive poly\u2010densified matrix hyaluronic acid and followed up for 90\u2013180\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 4\u2010month post injection evaluation, 93.3% of the patients presented at least 1\u2010grade improvement in the 5\u2010point scale as evaluated by the investigator. No serious adverse events were reported, being most mild and transient in nature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CaHA, incoBonTA, and CPM\u2010HA have complementary mechanisms of action and may be injected from the same syringe in the same session, boosting the final outcome, with high patient satisfaction, and ease of process for both patients and clinicians.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16296","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T05:39:42Z","timestamp":1712122782000},"page":"2392-2400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The gold protocol: A combined treatment approach for neck rejuvenation with calcium hydroxyapatite, botulinum toxin, and hyaluronic acid in the same 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