{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:12:32Z","timestamp":1791828752566,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pulsed\u2010dye lasers (PDL) are one of the standard therapies for rosacea, but alternatives are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the efficacy and safety of the variable\u2010sequenced, large\u2010spot 532\u2009nm KTP laser to the 595\u2009nm PDL in treating rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A prospective, controlled, evaluator\u2010blinded study. Patients were treated with either a KTP or PDL with 1\u20133 sessions at intervals of 6\u20138\u2009weeks. A follow\u2010up visit was scheduled on Week 6 post\u2010treatment. Clinical outcome was assessed by computer\u2010assisted analysis and by patients and two blinded dermatologists. Pain intensity during treatment and adverse events were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010five patients (mean age 51\u2009years) were allocated in a 2:1 ratio to either the KTP or PDL. Erythema in both treatment arms decreased significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Clinical evaluation revealed high improvement. Mean pain intensity was significantly lower with the KTP (2.5\/10) than with the PDL (4.1\/10). Both lasers showed a good safety profile. Relevant purpura was only seen in the PDL group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both the variable\u2010sequenced, large\u2010spot KTP and the PDL demonstrated comparable efficacy in treatment of rosacea. Regarding safety, the KTP exhibited fewer post\u2010treatment reactions. The KTP might serve as a potential alternative to PDL in the treatment of rosacea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16300","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T04:40:11Z","timestamp":1712810411000},"page":"2443-2449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Rosacea treatment with 532\u2009nm <scp>KTP<\/scp> versus 595\u2009nm pulsed dye laser\u2014A prospective, controlled study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1258-6390","authenticated-orcid":false,"given":"Lynhda","family":"Nguyen","sequence":"first","affiliation":[{"name":"Laser Department, Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Dierckxsens","sequence":"additional","affiliation":[{"name":"Amelio Clinic  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Kerscher","sequence":"additional","affiliation":[{"name":"Division of Cosmetic Sciences, Department of Chemistry University of Hamburg  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Hartjen","sequence":"additional","affiliation":[{"name":"Laser Department, Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan W.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Dermatology und Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Herberger","sequence":"additional","affiliation":[{"name":"Laser Department, Department of Dermatology and Venereology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1506630"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.15287"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15173"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.11.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1976"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003262.pub5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.077"},{"key":"e_1_2_11_9_1","unstructured":"PaaschU.S2k\u2010Leitlinie \u201eLasertherapie* der Haut\u201c (AWMF\u2010Registernr. 013\u2013095).2021."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.15181"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.958"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12878"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.044"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23439"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23605"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1528371"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2009.01156.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31802"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29181.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T02:22:31Z","timestamp":1718850151000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1111\/jocd.16300"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16300","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"assertion":[{"value":"2023-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}