{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:12:04Z","timestamp":1792141924801,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tear trough\u2010eye bag deformities may appear in young Asian patients due to the weak support of their facial skeletons. For these patients with better periorbital skin elasticity, the injection may be more suitable than surgery for treating tear trough\u2010lower eyelid bag deformity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Identify the clinical efficacy and safety of non\u2010cross\u2010linked HA in the treatment of tear trough\u2010lower eyelid bag deformity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we analyzed pre\u2010 and postinjection photographs of 55 patients treated with non\u2010cross\u2010linked hyaluronic acid (HA) for tear trough\u2010lower eyelid bag deformity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean [SD] scores of modified Goldberg score suggested that the most significant improvement of preoperative and postoperative scores was in tear trough depression, followed by infraorbital triangular depression, orbital fat prolapse, loss of skin elasticity, and skin transparency. Only transient localized complications were observed, including bruising, swelling, and erythema. There were no serious complications, such as skin necrosis or visual impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study confirmed the beneficial efficacy and minor complications of composite non\u2010cross\u2010linked HA for the treatment of tear trough\u2010lower eyelid bag deformity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16303","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T09:00:29Z","timestamp":1711616429000},"page":"2556-2562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical efficacy and safety of composite non\u2010cross\u2010linked hyaluronic acid for treating tear trough\u2010lower eyelid bag deformity"],"prefix":"10.1111","volume":"23","author":[{"given":"Xiaomei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College 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