{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:46:53Z","timestamp":1787053613515,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Vitiligo is a common depigmenting skin disorder. This work is performed to systematically evaluate the efficacy and safety of fire needles combined with 308\u2009nm excimer laser therapy in treating vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, Wanfang, and VIP databases. Randomized controlled trials (RCTs) on fire needles combined with 308\u2009nm excimer laser therapy with 308\u2009nm excimer laser therapy alone for vitiligo were included. The Cochrane Collaborative Network Tool was used to assess the risk of bias. Statistical analysis was completed using RevMan5.3 software and Stata 15.0 software. The GRADE system was used to evaluate the quality of evidence for outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In this study, 10 RCTs and 1333 patients were included. The results showed that compared with 308\u2009nm excimer laser therapy alone, fire needle combined with 308\u2009nm excimer laser therapy is more effective in improving clinical effective rate (RR\u2009=\u20091.36, 95% CI [1.24, 1.50], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), serum CD4+ level (MD\u2009=\u20093.12, 95% CI [2.50, 3.74], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), CD4+\/CD8+ ratio (MD\u2009=\u20090.24, 95% CI [0.09, 0.39], <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and quality of life measured by the Dermatology Life Quality Index (DLQI) (MD\u2009=\u20093.76, 95% CI [3.33, 4.19], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001), and reducing the Vitiligo Area Score Index (VASI) (MD\u2009=\u2009\u22125.47, 95% CI [\u22126.56, \u22124.37], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). The reported adverse events, including redness, swelling, pain, blisters, and itching, were controllable, and all these events were well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current evidence indicates that fire needle combined with 308\u2009nm excimer laser therapy is effective and safe for vitiligo. However, owing to the suboptimal quality of the included studies, more high\u2010quality and large\u2010scale RCTs are needed for comprehensive analysis and further validation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16308","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T08:48:41Z","timestamp":1712652521000},"page":"2592-2602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of fire needle combined with 308\u2009nm excimer laser therapy for vitiligo: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2269-5539","authenticated-orcid":false,"given":"Chenqi","family":"Guo","sequence":"first","affiliation":[{"name":"Graduate School Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junchen","family":"Li","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Graduate School Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100919-023531"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14713"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11197.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2240455"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9513762"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8797056"},{"issue":"9","key":"e_1_2_11_9_1","first-page":"936","article-title":"Observation on therapeutic effect of filiform fire needle assisted 308 nm excimer laser on vitiligo of different parts","volume":"39","author":"Sun LL","year":"2019","journal-title":"Chin Acupunct Moxibust"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"issue":"7","key":"e_1_2_11_11_1","first-page":"440","article-title":"Typing and therapeutic criteria for vitiligo (revised in 2003)","volume":"37","author":"Pigment disease Group of the Chinese Traditional and Western Medicine Integrated Dermatology and Venereology Professional Committee","year":"2004","journal-title":"Chin J Dermatol"},{"issue":"6","key":"e_1_2_11_12_1","first-page":"373","article-title":"Diagnosis and treatment standards for chloasma and vitiligo (2010 edition)","volume":"43","author":"Pigment Disease Group of the Chinese Traditional and Western Medicine Integrated Dermatology and Venereology Professional Committee","year":"2010","journal-title":"Chin J Dermatol"},{"issue":"4","key":"e_1_2_11_13_1","first-page":"247","article-title":"Consensus on the diagnosis and treatment of vitiligo (2018 edition)","volume":"51","author":"Xu AE","year":"2018","journal-title":"Chin J Dermatol"},{"issue":"4","key":"e_1_2_11_14_1","first-page":"251","article-title":"Guidelines for the treatment of vitiligo: a review of literature","volume":"38","author":"Li Y","year":"2012","journal-title":"Int J Dermatol Venereol"},{"key":"e_1_2_11_15_1","volume-title":"Chinese Clinical Dermatology","author":"Zhao B","year":"2010"},{"key":"e_1_2_11_16_1","first-page":"173","volume-title":"Dermatology and Venereology","author":"Zhang XJ","year":"2008"},{"key":"e_1_2_11_17_1","first-page":"123","volume-title":"Vitiligo and Chloasma","author":"Zhu WY","year":"2002"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.6.677"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21246"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"issue":"14","key":"e_1_2_11_22_1","first-page":"76","article-title":"A randomized controlled study on vitiligo by combination pf filiform fire needle, 308 excimer light and tacrolimus ointment","volume":"44","author":"Wang XD","year":"2023","journal-title":"J Medical Forum"},{"issue":"3","key":"e_1_2_11_23_1","first-page":"343","article-title":"Observation on the curative effect of fire needling therapy combined with 308 nm excimer light in the treatment of vitiligo","volume":"31","author":"Qiu DX","year":"2022","journal-title":"Mod J Integr Tradit Chin West Med"},{"issue":"13","key":"e_1_2_11_24_1","first-page":"21","article-title":"The effect of 308 nm excimer laser combined with fire needle therapy on facial vitiligo and its impact on T lymphocyte subsets and inflammatory factors in patients","volume":"20","author":"Xue GX","year":"2022","journal-title":"Contemp Med Symp"},{"issue":"4","key":"e_1_2_11_25_1","first-page":"110","article-title":"Efficacy of flat\u2010end fire needle combined with 308 nm excimer laser in the treatment of vitiligo and its influence on levels of Endothelin\u20101 and Interleukin\u201017 in skin lesions tissues","volume":"31","author":"Zhang YZ","year":"2022","journal-title":"Chin J Aesthet Med"},{"issue":"1","key":"e_1_2_11_26_1","first-page":"185","article-title":"The effect of 308nm excimer phototherapy combined with fire acupuncture on the skin lesion area of vitiligo patients","volume":"39","author":"Ou YF","year":"2021","journal-title":"J Sichuan Tradit Chin Med"},{"issue":"3","key":"e_1_2_11_27_1","first-page":"102","article-title":"Effect of Millifire needle assisted 308nm excimer laser combine with tacrolimus ointment on immune function of patients with vitiligo","volume":"30","author":"Ren H","year":"2021","journal-title":"Chin J Aesthet Med"},{"issue":"8","key":"e_1_2_11_28_1","first-page":"844","article-title":"The therapeutic effect of fire needle combined with 308 nm excimer laser on vitiligo and its impact on the area of vitiligo","volume":"29","author":"Liu CL","year":"2020","journal-title":"Chin J Convalescent Med"},{"issue":"10","key":"e_1_2_11_29_1","first-page":"1051","article-title":"Efficacy observation of milli\u2010fire needle combined with 308nm excimer laser for stable vitiligo","volume":"53","author":"Xu CQ","year":"2018","journal-title":"Jiangxi Med J"},{"issue":"15","key":"e_1_2_11_30_1","first-page":"96","article-title":"Curative effect observation and nursing care of milli fire needle combined with 308 nm excimer laser in treating vitiligo","volume":"9","author":"Yu CD","year":"2017","journal-title":"Clin J Chin Med"},{"issue":"4","key":"e_1_2_11_31_1","first-page":"81","article-title":"Clinical study on the treatment of vitiligo with fire needle combined with 308nm excimer light","volume":"10","author":"Dun G","year":"2016","journal-title":"Chin J Clin"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11008.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31101"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-012-1185-1"},{"issue":"6","key":"e_1_2_11_35_1","first-page":"549","article-title":"Exploring the etiology, pathogenesis, and treatment principles of vitiligo again from ancient Chinese medicine literature","volume":"21","author":"Zhao YX","year":"2022","journal-title":"Chin J Dermato Venerol Integ Trad W Med"},{"issue":"2","key":"e_1_2_11_36_1","first-page":"43","article-title":"Clinical observation on fire needle and Chinese medicine combination for the treatment of blood stasis type of vitiligo","volume":"37","author":"Zhao Y","year":"2015","journal-title":"J Guiyang College Tradit Chin Med"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21754"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:20:33Z","timestamp":1735298433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,9]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jocd.16308"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16308","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,9]]},"assertion":[{"value":"2024-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}