{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:14:44Z","timestamp":1787015684095,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There is a dearth of effective treatments to counter retinol\u2010induced skin irritation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the efficacy of three potential mitigants: (i) phytosteryl\/octyldodecyl lauroyl glutamate (PLG), (ii) a physiologic lipid mixture (PLM) comprised of ceramide three and cholesterol, and (iii) niacinamide, in ameliorating irritation instigated by retinol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An occlusive human patch test, spanning 5\u2009days, was undertaken on 18 Chinese participants aged between 23 and 40. It was designed as a randomized, double\u2010blind, and vehicle\u2010controlled study. Clinician erythema assessment (CEA) and instrumental evaluations were employed pre and post\u2010test. Subsequently, a 4\u2010week consumer in\u2010use test, randomized and double\u2010blind in nature, was executed to substantiate the soothing effects of PLG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data from CEA and bioengineering assessments revealed that, in comparison to the vehicle control, both 2% PLG and 5% PLM notably curbed retinol\u2010induced skin erythema and inflammation. Notably, PLG outperformed PLM. Conversely, 3% niacinamide did not offer relief against retinol\u2010induced discomfort. The subsequent consumer in\u2010use test affirmed that treatments with 2% PLG were better tolerated than those with the vehicle alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To the best of our knowledge, this study represents the first confirmation that physiologic lipids effectively mitigate retinol\u2010induced irritation. Given their capacity to counter retinol\u2010induced irritation, physiologic lipids, particularly PLG, are recommended for incorporation in retinol regimens. Additionally, the Visia\u2010CR a* value can serve as a robust objective measure for interpreting patch test outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16330","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T02:53:54Z","timestamp":1713322434000},"page":"2743-2749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mitigation of retinol\u2010induced skin irritation by physiologic lipids: Evidence from patch testing"],"prefix":"10.1111","volume":"23","author":[{"given":"Ye","family":"Fang","sequence":"first","affiliation":[{"name":"Research &amp; Innovation Center Proya Cosmetics Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ying","sequence":"additional","affiliation":[{"name":"Research &amp; Innovation Center Proya Cosmetics Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiaolan","sequence":"additional","affiliation":[{"name":"Research &amp; Innovation Center Proya Cosmetics Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun","family":"Lin","sequence":"additional","affiliation":[{"name":"Research &amp; Innovation Center Proya Cosmetics Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chenlan","sequence":"additional","affiliation":[{"name":"Research &amp; Innovation Center Proya Cosmetics Co., Ltd.  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Caixia","sequence":"additional","affiliation":[{"name":"Research &amp; Innovation Center Proya Cosmetics Co., Ltd.  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