{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:08:25Z","timestamp":1791842905294,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Dark eye circle (DEC) is one of the most common cosmetic problems. It has a great impact on the patients' quality of life. Carboxytherapy is a cosmetic technique using pure carbon dioxide for different uses in different areas of the body. The goal of this study is to evaluate the efficacy and tolerability of carboxytherapy in the cosmetic correction of DECs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted on 27 patients requesting the correction of DEC. The treatment was performed using a carboxy device in medical grade. The gas injection was performed intradermal after local anesthesia, with a pressure of one tenth bar and a speed of 20\u2009cc\/min, 1 cc in each upper and lower eyelid. The treatment sessions were done every 2\u2009weeks for four sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean physicians' score of DECs before and after treatment was 8.7\u2009\u00b1\u20090.81 and 4.6\u2009\u00b1\u20091.1, respectively. The mean patients' score before and after treatment was 9.2\u2009\u00b1\u20090.5 versus 5.41\u2009\u00b1\u20091.37. The mean scores showed a significant reduction of skin discoloration without major side effects (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Carboxytherapy seems to be an effective treatment option for dark circles around the eyes with a good safety profile and patient satisfaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16331","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T04:44:02Z","timestamp":1717476242000},"page":"2711-2715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of the effects of carboxytherapy in the treatment of periorbital dark circles"],"prefix":"10.1111","volume":"23","author":[{"given":"Seyed Mehdi","family":"Tabaie","sequence":"first","affiliation":[{"name":"Department of Medical Laser, Medical Laser Research Center Yara Institute, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-8847","authenticated-orcid":false,"given":"Afshan","family":"Shirkavand","sequence":"additional","affiliation":[{"name":"Department of Photodynamic, Medical Laser Research Center Yara Institute, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Department of Medical Laser, Medical Laser Research Center Yara Institute, ACECR  Tehran Iran"},{"name":"Skin and Stem Cell Research Center, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Asghar Haeri","family":"Mehrizi","sequence":"additional","affiliation":[{"name":"Health Metrics Research Center, Iranian Institute for Health Sciences Research, ACECR  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0575-4381","authenticated-orcid":false,"given":"Susan","family":"Farshi","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12536"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2012.00633.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.184046"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S102503"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2016.4225"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1980.tb02000.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1954.28"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32161.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1493512"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30677-6"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-021-03274-5"},{"issue":"5","key":"e_1_2_11_13_1","first-page":"42","article-title":"Carboxytherapy non\u2010invasive method in dermatology and some other branches of medicine","volume":"3","author":"Zelenkova H","year":"2019","journal-title":"ASMS"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12668"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580080114013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06346.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.200408.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.04.006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(91)90186-K"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.039"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1975.01630130042004"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001897"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2021.01.028"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.3.312"},{"issue":"9","key":"e_1_2_11_25_1","first-page":"976","article-title":"Effect of carbon dioxide facial therapy on skin oxygenation","volume":"14","author":"Seidel R","year":"2015","journal-title":"J Drugs Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:19:37Z","timestamp":1735298377000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jocd.16331"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16331","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]},"assertion":[{"value":"2023-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}