{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:03:39Z","timestamp":1770915819739,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T00:00:00Z","timestamp":1713571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia (AGA) is a major cause of hair loss resulting from a complex interplay between various genes and hormones with the result being follicular miniaturization and altered hair cycle dynamics. Platelet\u2010rich plasma (PRP) has a well\u2010established role as adjunctive therapy in AGA but there are many limitations of it. In an attempt to overcome the shortcomings of PRP, liquid platelet\u2010rich fibrin (PRF) was developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This article critically reviews the protocol for the preparation and clinical outcomes of PRF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>The articles published so far in the English language regarding the preparation and clinical outcomes of PRF were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among five studies analyzing various centrifugation speeds and centrifugation times, three of the studies favored low\u2010speed centrifugation, whereas two studies did not support this methodology. A horizontal centrifuge may be preferred over a fixed\u2010angle centrifuge for PRF. Five clinical studies on the use of PRF showed a significant effect on AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At present, there is no consensus regarding the preparation of PRF. Most studies used fixed\u2010angle centrifugation favored low centrifuge speed and less centrifugation time. Larger studies are needed to determine the optimal centrifugation force and time. A horizontal centrifuge may be preferred over a fixed\u2010angle centrifuge due to the higher yield of platelets, and lesser shear trauma to the cells. In addition, larger, well\u2010designed studies are needed to confirm the benefits of PRF over PRP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16333","type":"journal-article","created":{"date-parts":[[2024,4,20]],"date-time":"2024-04-20T07:49:00Z","timestamp":1713599340000},"page":"2524-2530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Platelet\u2010rich fibrin: A review of its role as a new treatment in androgenetic alopecia"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-8619","authenticated-orcid":false,"given":"Samir","family":"Shrestha","sequence":"first","affiliation":[{"name":"Department of Dermatology Rapti Province Hospital  Dang, Tulsipur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5161-4374","authenticated-orcid":false,"given":"Raksha","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pokhara Academy of Health Sciences  Pokhara Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. C.","family":"Jagat","sequence":"additional","affiliation":[{"name":"Sathi Polyclinic  Dang, Tulsipur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of British Columbia  Vancouver British Columbia Canada"},{"name":"Donovan Hair Clinic  Whistler British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,20]]},"reference":[{"key":"e_1_2_14_2_1","first-page":"53","article-title":"Incidence of female androgenetic alopecia (female pattern alopecia)","volume":"27","author":"Norwood OT","year":"2001","journal-title":"Dermatologic Surg"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03030.x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines7020027"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-023-03603-9"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_74_16"},{"issue":"1","key":"e_1_2_14_7_1","first-page":"24","article-title":"Platelet\u2010rich plasma for the treatment of alopecia: a systematic review and meta\u2010analysis","volume":"21","author":"Cruciani M","year":"2023","journal-title":"Blood Transfus"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13742"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1293807"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175070"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-016-0052-4"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160443"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03303-7"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1717455"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01497-0"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-017-5992-6"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-017-0767-9"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-017-2063-9"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-020-01299-w"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36734"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36346"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_73_18"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2455-4529.IntJResDermatol20221637"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001584"},{"issue":"9","key":"e_1_2_14_25_1","first-page":"29","article-title":"Study on the efficacy of platelet\u2010rich fibrin matrix in hair follicular unit transplantation in androgenetic alopecia patients","volume":"9","author":"Mahapatra S","year":"2016","journal-title":"J Clin Aesthet Dermatol"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T11:19:26Z","timestamp":1735298366000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,20]]},"references-count":24,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1111\/jocd.16333"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16333","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,20]]},"assertion":[{"value":"2024-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}