{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:23:28Z","timestamp":1789068208464,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      To date, a consensus on the relative efficacy and safety of CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser versus erbium\u2010doped yttrium aluminum garnet (Er:YAG) fractional laser treatments for atrophic acne scars has not been reached. This meta\u2010analysis aims to systematically assess and compare their effectiveness and safety in clinical practice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      For this meta\u2010analysis, we conducted comprehensive searches in Pubmed, Embase, and Cochrane databases, covering publications from their inception up to August 2023. Our focus was on studies comparing fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      laser with Er:YAG fractional laser treatments for atrophic acne scars. We excluded duplicate publications, research lacking full\u2010text access, incomplete data, or cases where data extraction was not feasible. Additionally, animal experiments, reviews, and systematic reviews were not considered. Data analysis was performed using STATA 15.1.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies (seven randomized controlled trials (RCTs) and a retrospective study) were included in this meta\u2010analysis. The sample size ranged from 28 to 106 with a total of 418 patients, including 210 in the CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional group and 208 in Er:YAG fractional group. The pooled results showed that the effective rate of CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser in treating atrophic acne scar was significantly higher than that of Er:YAG fractional laser (OR\u2009=\u20091.81, 95% CI: 1.08\u20133.01) and the downtime of CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser in treating atrophic acne scar was significantly shorter than that of Er:YAG fractional laser (Weighted Mean Difference (WMD)\u2009=\u2009\u22122.11, 95% CI: \u22123.11 to \u22121.10). In addition, VAS of CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser in treating atrophic acne scar was significantly higher than that of Er:YAG fractional laser (WMD\u2009=\u20091.77, 95% CI: 1.32\u20132.21) and the duration of erythema of CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser in treating atrophic acne scar was significantly longer than that of Er:YAG fractional laser (WMD\u2009=\u20091.85, 95% CI: 1.63\u20132.07). However, there was no significant difference in the duration of pain and incidence of PIHbetween CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser and of Er:YAG fractional laser.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      When it comes to treating atrophic acne scars, CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser demonstrates superior efficacy and leads to shorter downtime. However, it is important to note that CO\n                      <jats:sub>2<\/jats:sub>\n                      fractional laser treatments tend to result in higher pain intensity and may carry a higher risk of post\u2010treatment pigmentation compared to Er:YAG fractional laser procedures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16348","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T01:39:12Z","timestamp":1715391552000},"page":"2768-2778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and safety of\n                    <scp>\n                      CO\n                      <sub>2<\/sub>\n                    <\/scp>\n                    fractional laser versus Er:\n                    <scp>YAG<\/scp>\n                    fractional laser in the treatment of atrophic acne scar: A meta\u2010analysis and systematic review"],"prefix":"10.1111","volume":"23","author":[{"given":"Fei","family":"Liu","sequence":"first","affiliation":[{"name":"Jinhua People's Hospital  Jinhua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-3423","authenticated-orcid":false,"given":"Qiujun","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Zhejiang Chinese Medical University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0530-9528","authenticated-orcid":false,"given":"Maocan","family":"Tao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Shu","sequence":"additional","affiliation":[{"name":"Jinhua Shuhe Plastic Surgery Clinic  Jinhua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou 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