{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:48:40Z","timestamp":1785912520278,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673082"],"award-info":[{"award-number":["81673082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972954"],"award-info":[{"award-number":["81972954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Phakomatosis pigmentovascularis (PPV) is a rare congenital syndrome. Only a few studies have reported the treatment of PPV, including a case using photodynamic therapy (PDT) to treat PPV\u2010associated port\u2010wine stains (PWS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigating the efficacy and adverse effects of hemoporfin\u2010PDT in PPV\u2010associated PWS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The efficacy and adverse effects in patients with PPV who underwent two sessions of hemoporfin\u2010PDT from January 2019 to December 2022 were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty patients were included (13 females, 7 males, age range: 2\u201331\u2009years; mean: 8.20\u2009\u00b1\u20098.92\u2009years). Two, nine, seven, and two patients had PPV types Ia, IIa, IIb, and IIIa, respectively. After two treatments, the visual evaluation indicated the color of the PWS in 4, 5, 6, and 5 patients showed poor, fair, good, and excellent improvements, respectively. The combined good and excellent improvement rates in patients with PWS and pigmentary nevus overlapping in the same treatment area and in patients with PWS in the treatment areas only were 33.3% versus 87.5%, respectively, and were significantly different (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Minor side effects, such as edema, scabbing, hyperpigmentation, and blistering, were observed in some patients after PDT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hemoporfin\u2010PDT is an effective treatment for PPV\u2010associated PWS. Patients with PWS and pigmentary nevus overlapping in the same treatment area showed poorer efficacy than patients with PWS in the treatment areas only.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16351","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:40:07Z","timestamp":1715568007000},"page":"2888-2894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Photodynamic therapy for the treatment of port\u2010wine stains in phakomatosis pigmentovascularis"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3429-9584","authenticated-orcid":false,"given":"Yuanbo","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)  Nanjing 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Venereology The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixin","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province Hospital)  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.027"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00403.x"},{"key":"e_1_2_12_4_1","first-page":"1806","volume-title":"Editors.Fitzpatrick's Dermatology in General Medicine","author":"Happle 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