{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:12:00Z","timestamp":1791389520980,"version":"4.3.3"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Alopecia areata (AA) is a recurrent immune\u2010mediated disorder causing hair loss without any scarring being present. It affects hairs on the head or other parts of the body and can occur at any age and in both genders. It seems that AA is associated with a higher rate of psychological disorders resulting from hair loss and the esthetic and social repercussions of it. Common treatments like corticosteroids do not work for every patient and recent treatment options focusing on the immunologic mechanisms like tofacitinib have shown some promising results.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n It's a retrospective study on patients with AA, AT, AU taking oral tofacitinib as a treatment for at least 6\u2009months. Scalp hair loss was assessed before treatment and at each visit using the Severity of Alopecia Tool (SALT) score.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 97 cases, 69.1% demonstrated over 50% SALT score improvement, with 44.3% having 90% or more decrease in SALT score. Patients who suffered from patchy AA were more responsive compared to patients with AT and AU subtypes and had a greater percent change in SALT score. Tofacitinib was tolerated quite well and no significant adverse events were reported.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Tofacitinib should be taken into consideration as an efficacious treatment option for patients with AA, AT and AU.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.16356","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T01:53:42Z","timestamp":1715565222000},"page":"2807-2813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Safety and efficacy of tofacitinib in 97 alopecia areata patients"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0571-5940","authenticated-orcid":false,"given":"Maryam","family":"Nasimi","sequence":"first","affiliation":[{"name":"Dermatology, Dermatology Department Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robabeh","family":"Abedini","sequence":"additional","affiliation":[{"name":"Dermatology, Dermatology Department Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Ghandi","sequence":"additional","affiliation":[{"name":"Dermatology, Dermatology Department Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Teymourpour","sequence":"additional","affiliation":[{"name":"Statistics, Blood transfusion Research Center High Institute for Research and Education Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5223-5391","authenticated-orcid":false,"given":"Hanie","family":"Babaie","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_99_17"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01862"},{"key":"e_1_2_10_4_1","volume-title":"StatPearls","author":"Padda 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comparative safety study of tofacitinib and biological disease\u2010modifying antirheumatic drugs: 5\u2010year results from a United States\u2010based rheumatoid arthritis registry ACR open","volume":"3","author":"Kremer JM","year":"2021","journal-title":"Rheumatology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42250"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.09.007"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.89776"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15489"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/15569527.2022.2084622"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2007.03.004"}],"container-title":["Journal of Cosmetic 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