{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:35:17Z","timestamp":1788388517682,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013129","name":"Ministry of SMEs and Startups","doi-asserted-by":"publisher","award":["S3003957"],"award-info":[{"award-number":["S3003957"]}],"id":[{"id":"10.13039\/501100013129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA) is a common and chronic problem characterized by hair follicle miniaturization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      In this study, heat\u2010treated\n                      <jats:italic>Limosilactobacillus fermentum<\/jats:italic>\n                      LM1020 (HT\u2010LM1020) was investigated in human follicle dermal papilla cell (HFDPC), scalp tissue, and clinical trials for patients with AGA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>Cell proliferation and the expression of cyclins and cyclin\u2010dependent kinases (CDKs) were measured in HFDPC. The relative gene expression of 5\u03b1\u2010reductase and growth factors were investigated in hair scalp. This double\u2010blind, randomized, placebo\u2010controlled clinical trial was conducted over 24\u2009weeks. Primary efficacy was evaluated by measuring hair density, and secondary efficacy was assessed by experts and self\u2010assessment. Changes in the microbiota of the hair scalps were analyzed using 16S metagenome amplicon sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HT\u2010LM1020 promoted cell growth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and cyclin B1 expression, and it reduced 5\u03b1\u2010reductase and induced fibroblast growth factor 7 (FGF7), FGF10, and epithelial growth factor7 (EGF7) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In the clinical trial, the experimental group demonstrated an increase in hair density from 133.70 to 148.87\u2009n\/cm\n                      <jats:sup>2<\/jats:sup>\n                      at Week 24 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while also expressing satisfaction with their hair density, reduced hair loss, and hairline. At Week 24, the total ratio of lactic acid bacteria operational taxonomic unit (OTU) in the scalp increased from 6.65% to 26.19%. At the same period, placebo\u2010controlled group decreased\n                      <jats:italic>Staphylococcus caprae<\/jats:italic>\n                      OTU from 77.95% to 14.57% while experimental group decreased from 65.80% to 41.02%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These present results showed that HT\u2010LM1020 was a co\u2010effector of ingredients for anti\u2010hair loss contributing to cell proliferation and the expression of CDKs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16357","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T03:05:54Z","timestamp":1716951954000},"page":"2943-2955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Heat\u2010treated\n                    <i>Limosilactobacillus fermentum<\/i>\n                    <scp>LM1020<\/scp>\n                    with menthol, salicylic acid, and panthenol promotes hair growth and regulates hair scalp microbiome balance in androgenetic alopecia: A double\u2010blind, randomized and placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6615-2547","authenticated-orcid":false,"given":"Won\u2010Young","family":"Bae","sequence":"first","affiliation":[{"name":"Microbiome R&amp;D Center Lactomason  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-1973","authenticated-orcid":false,"given":"Woo\u2010Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Microbiome R&amp;D Center Lactomason  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1683-4638","authenticated-orcid":false,"given":"So 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