{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:49:01Z","timestamp":1783406941140,"version":"3.54.6"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The evidence base pertaining to the efficacy of monotherapies for androgenetic alopecia (AGA), the most common form of hair loss, is ever expanding\u2014and this warrants a formal comparison therapies' effect on a frequent basis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of the current study was to determine the comparative effect of relevant monotherapies for male AGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients\/Methods<\/jats:title>\n                    <jats:p>Our aim was achieved by conducting Bayesian network meta\u2010analysis (NMA), under a random effects model, for two outcomes: 6\u2010month change in (1) total and (2) terminal hair density in adult (i.e., aged 18\u2009years and above) men with AGA; these analyses were preceded by a systematic search of the peer\u2010reviewed literature for suitable data. Interventions' surface under the cumulative ranking curve (SUCRA) and pairwise relative effects (quantified as mean differences) were estimated through the NMAs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We determined the comparative effect of 20 active comparators and a control (i.e., placebo\/vehicle). \u201cDutasteride 0.5 mg once daily for 24\u2009weeks\u201d was ranked the most effective in terms of 6\u2010month change in (1) total hair density (SUCRA\u2009=\u200987%) and terminal hair density (SUCRA\u2009=\u200998%). Our results showed that interventions\u2019 effectiveness can be dose dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our updated analyses of the up\u2010to\u2010date evidence regarding monotherapies for male AGA showed that the oral form of 5\u2010alpha reductase inhibitors are more effective than oral minoxidil and other newer agents like Botox, microneedling, and photobiomodulation. Our findings can better inform clinical decision making and design of future research studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16362","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:39:47Z","timestamp":1715301587000},"page":"2964-2972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impact of monotherapies for male androgenetic alopecia: A network meta\u2010analysis study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine University of Toronto School of Medicine  Toronto Ontario Canada"},{"name":"Mediprobe Research Inc.  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Bamimore","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc.  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Wang","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc.  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0691-640X","authenticated-orcid":false,"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.084"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.5743"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000534196"},{"key":"e_1_2_11_6_1","article-title":"The comparative effect of monotherapies for male androgenetic alopecia: a protocol for network meta\u2010analysis study","author":"Gupta AK","year":"2024","journal-title":"Int Platform Reg Syst Rev Meta\u2010Analy Protocols"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_11_10_1","unstructured":"Posit team.RStudio: Integrated Development Environment for R.2022."},{"key":"e_1_2_11_11_1","volume-title":"Network Meta\u2010Analysis Using Bayesian Methods","author":"Valkenhoef G","year":"2020"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8139"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1428"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/1536867x0400400204"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.22034\/ijd.2022.308979.1442"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05435.x"},{"key":"e_1_2_11_17_1","unstructured":"U.S. Food and Drug Administration.Prescribing Information for PROPECIA (finasteride) tablets. 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