{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:41:14Z","timestamp":1792003274254,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2020FZZX008\u201004"],"award-info":[{"award-number":["2020FZZX008\u201004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2023QZJH60"],"award-info":[{"award-number":["2023QZJH60"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022963","name":"Key Research and Development Program of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03072"],"award-info":[{"award-number":["2023C03072"]}],"id":[{"id":"10.13039\/100022963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Botulinum neurotoxin injections are the most frequently performed cosmetic procedures, but conventional blind injection for glabellar wrinkles remains to have some limitations.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n We intend to directly inject botulinum neurotoxin into the glabella complex guided by real time ultrasound. We aim to propose a more efficient and safer botulinum neurotoxin injection strategy for glabellar wrinkles.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 40 subjects with moderate to severe glabellar lines were enrolled in this study to receive botulinum neurotoxin injection, either through ultrasound\u2010guided real time injection or conventional blind injection. Facial Wrinkle Scale (ranging from 0\u2009=\u2009none to 3\u2009=\u2009severe) and inter\u2010brow distance (from 3D scanned face images) were used to evaluate the glabellar wrinkles improvement. Paired\n t<\/jats:italic>\n test and two\u2010sample\n t<\/jats:italic>\n test were performed to analyze the within\u2010group and between\u2010group differences.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The wrinkle score reduction was significant (\n p<\/jats:italic>\n \u2009<\u20090.0001) immediately after the injection in ultrasound\u2010guided injection group, but not in blind injection group (\n p<\/jats:italic>\n \u2009=\u20090.163). Ultrasound\u2010guided injection also showed a higher performance of wrinkle score reduction and more effective inter\u2010brow distance increase over blind injection at Day 0 (\n p<\/jats:italic>\n \u2009<\u20090.0001), Day 1 (\n p<\/jats:italic>\n \u2009<\u20090.0001), Day 21 (\n p<\/jats:italic>\n \u2009<\u20090.01) and Day 35 (\n p<\/jats:italic>\n \u2009<\u20090.01) after initial treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The results of the study confirmed that botulinum neurotoxin injection for glabellar wrinkles under ultrasound guidance achieves quicker onset of action and better final outcomes compared to conventional blind injection.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.16365","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T06:04:56Z","timestamp":1715321096000},"page":"2867-2875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A prospective and randomized study comparing\n ultrasound\u2010guided<\/scp>\n real time injection to conventional blind injection of botulinum neurotoxin for glabellar wrinkles"],"prefix":"10.1111","volume":"23","author":[{"given":"Yange","family":"Wu","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Li","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Lin","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengni","family":"Ye","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuepeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuangyun","family":"Tang","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province Cancer Center of Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"168","article-title":"Botulinum toxin injection for facial wrinkles","volume":"90","author":"Small R","year":"2014","journal-title":"Am Fam 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