{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:34:11Z","timestamp":1790109251085,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Male androgenetic alopecia (MAA) is a multifactorial disease, with patients presenting at a younger age, which is a risk factor for many metabolic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To explore the risk factors associated with early\u2010onset of MAA and its metabolic characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty patients with MAA and 45 healthy controls were collected. The serum levels of fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high\u2010density lipoprotein cholesterol (HDL\u2010C), low\u2010density lipoprotein cholesterol (LDL\u2010C), total testosterone (TT), uric acid (UA), and 25\u2010hydroxyvitamin D (25(OH)D) were measured. Meanwhile, lipid metabolites were detected by ultra\u2010high\u2010performance liquid chromatography\u2013tandem mass spectrometry (UHPLC\u2013MS\/MS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      37.50% MAA patients had metabolic syndrome, compared to 17.78% in control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The levels of HDL\u2010C, UA, and 25(OH)D were decreased in patients with MAA compared to healthy controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, there was no significant difference in the level of TT between the two groups. Additionally, there were no significant differences in the levels of HDL\u2010C, UA, 25(OH)D, and TT among different grades of hair loss (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). The lipid profile of early\u2010onset MAA differed significantly from healthy controls. In early\u2010onset MAA, the levels of ceramide (Cer) and sphingomyelin (SM) were significantly lower. Cer(d38:5) and TG(15:0\/18:1\/18:1) may be the biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low HDL\u2010C, UA, and 25(OH)D may be the independent risk factors for early\u2010onset MAA. Abnormal lipid metabolism was observed in early\u2010onset MAA, wherein Cer and SM may serve as protective factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16371","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T05:19:29Z","timestamp":1715577569000},"page":"3038-3044","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors and lipid metabolism characteristics of early\u2010onset male androgenetic alopecia: A pilot study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-6599","authenticated-orcid":false,"given":"Shuqin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei Anhui China"},{"name":"Department of Dermatology Anhui Public Health Clinical Center  Hefei Anhui 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