{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:12:57Z","timestamp":1778915577909,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"publisher","award":["988037"],"award-info":[{"award-number":["988037"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background &amp; Aim<\/jats:title>\n                    <jats:p>Rosacea is a chronic inflammatory, multifactorial disease for which combination therapy could be an effective treatment.<\/jats:p>\n                    <jats:p>In this study, we evaluate the effect of the combination therapy of brimonidine 0.33% and ivermectin 1% as a single cream for the treatment of papulopustular rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A stable and appropriate formulation was prepared by adding the aqueous phase to the lipid phase while being stirred. The stability and physicochemical properties of the formulation were evaluated under accelerated conditions. Twelve patients (36\u201360\u2009years) with mild to moderate papulopustular rosacea and a Demodex count of five or more were treated with the combination of brimonidine 0.33% and ivermectin 1% cream. Clinician's Erythema Assessment (CEA), Patients Self\u2010Assessment (PSA), skin erythema (\u0394E) and lightness (\u0394L), and skin biophysical parameters including transepidermal water loss (TEWL), skin hydration, pH, and sebum content, as well as erythema and melanin index and ultrasound parameters, were measured before treatment and 4 and 8\u2009weeks after. Adverse drug reactions were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CEA and PSA decreased significantly from 3 to 2 after 8\u2009weeks, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009=\u20090.014 for CEA and 0.010 for PSA). \u0394E and \u0394L, as well as skin erythema index and TEWL improved after 8\u2009weeks of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Two patients withdrew from the study in the first week because of local adverse effects; one developed flushing following treatment and left the investigation after 4\u2009weeks and another patient withdrew from the study after 4\u2009weeks due to deciding to become pregnant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Eight\u2010week treatment with the combination of brimonidine 0.33% and ivermectin 1% was shown to be effective for improvement of erythema and inflammatory lesions in mild to moderate papulopustular rosacea.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16372","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:58:21Z","timestamp":1717462701000},"page":"2973-2981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fabrication and efficacy assessment of combination of brimonidine and ivermectin for treatment of papulopustular rosacea"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8518-4669","authenticated-orcid":false,"given":"Samin Fallah","family":"Pakdaman","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Branch, Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-429X","authenticated-orcid":false,"given":"Aniseh","family":"Samadi","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Training in Skin Diseases &amp; Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3613-4644","authenticated-orcid":false,"given":"Mahsa","family":"Fattahi","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Training in Skin Diseases &amp; Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-4918","authenticated-orcid":false,"given":"Atefeh","family":"Naeimifar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-5240","authenticated-orcid":false,"given":"Fatemeh Amiri","family":"Ardehali","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Training in Skin Diseases &amp; Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-9391","authenticated-orcid":false,"given":"Yasaman","family":"Ketabi","sequence":"additional","affiliation":[{"name":"Shahid Beheshti University of Medical Science  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-6686","authenticated-orcid":false,"given":"Saman Ahmad","family":"Nasrollahi","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Training in Skin Diseases &amp; Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7274-4840","authenticated-orcid":false,"given":"Alireza","family":"Firooz","sequence":"additional","affiliation":[{"name":"Center for Research &amp; Training in Skin Diseases &amp; Leprosy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00595-7"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.045"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00218.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15173"},{"issue":"6","key":"e_1_2_11_6_1","first-page":"650","article-title":"Efficacy and safety of once\u2010daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double\u2010blind, and vehicle\u2010controlled pivotal studies","volume":"12","author":"Fowler J","year":"2013","journal-title":"J Drugs 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results of a 1\u2010year open\u2010label study","volume":"13","author":"Moore A","year":"2014","journal-title":"J Drugs Dermatol"},{"issue":"8","key":"e_1_2_11_15_1","first-page":"896","article-title":"Retrospective analysis of the association between Demodex infestation and rosacea [published correction appears in arch Dermatol. 2010 dec;146(12):1412]","volume":"146","author":"Zhao YE","year":"2010","journal-title":"Arch Dermatol"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_514_17"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03704.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.048090-0"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.01.853"},{"issue":"6","key":"e_1_2_11_20_1","first-page":"763","article-title":"Paradoxical erythema reaction of long\u2010term topical brimonidine gel for the treatment of facial erythema of rosacea","volume":"15","author":"Lowe E","year":"2016","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S115708"},{"issue":"9","key":"e_1_2_11_22_1","first-page":"909","article-title":"Treatment of rosacea with concomitant use of topical ivermectin 1% cream and brimonidine 0.33% gel: a randomized, vehicle\u2010controlled study","volume":"16","author":"Gold LS","year":"2017","journal-title":"J Drugs Dermatol"}],"container-title":["Journal of Cosmetic 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