{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:17Z","timestamp":1791507137789,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Seborrheic dermatitis (SD) poses significant treatment challenges due to its chronic nature and the side effects associated with long\u2010term use of conventional therapies like topical corticosteroids. In the search for alternative treatments, exosomes, particularly those derived from rose stem cells (RSCEs), offer a promising avenue due to their potential in managing chronic skin conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This case report examines the efficacy of a topical moisturizer containing RSCEs in treating a patient with refractory SD, aiming to provide an alternative treatment pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A 40\u2010year\u2010old male with a long\u2010standing history of SD, unresponsive to traditional treatments, underwent a novel treatment regimen. This regimen included an initial topical application of 2.5\u2009mL of RSCEs followed by a maintenance phase involving the application of a RSCE\u2010containing moisturizer. Clinical outcomes were assessed through the Patient's Global Assessment (PGA) and Investigator's Global Assessment (IGA) scores, along with evaluations of scaling and erythema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Remarkable clinical improvement was noted as early as 1\u2010day post\u2010treatment, with significant reductions in redness, scaling, and itching. The patient experienced sustained relief throughout the 6\u2010month follow\u2010up, with a recurrence in the sixth month that was less severe than previous flare\u2010ups. This demonstrated not only the efficacy of RSCEs in symptom management but also their potential in extending remission periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The chronic management of SD can benefit from innovative treatments like the RSCE\u2010containing moisturizer, as shown in this case report. While the observed outcomes are promising, indicating substantial improvements in skin condition and symptom management, larger controlled studies are necessary to validate the therapeutic potential of exosome\u2010containing moisturizers fully. This case underscores the need for alternative therapies in SD treatment, highlighting the role of exosomes as a viable option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16389","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T01:41:04Z","timestamp":1717465264000},"page":"3128-3132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Topical moisturizer with rose stem cell\u2010derived exosomes (RSCEs) for recalcitrant seborrheic dermatitis: A case report with 6\u2009months of follow\u2010up"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2982","authenticated-orcid":false,"given":"Suparuj","family":"Lueangarun","sequence":"first","affiliation":[{"name":"Department of Aesthetic Medicine College of Integrative Medicine, Dhurakij Pundit University  Bangkok Thailand"},{"name":"Division of Dermatology DeMed Clinic Center  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5666-2666","authenticated-orcid":false,"given":"Byong Seung","family":"Cho","sequence":"additional","affiliation":[{"name":"ExoCoBio Exosome Institute (EEI) ExoCoBio Inc.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-2135","authenticated-orcid":false,"given":"Therdpong","family":"Tempark","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital Chulalongkorn University  Pathum Wan Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.01.001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000076478"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02123.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00693.x"},{"issue":"6","key":"e_1_2_11_6_1","first-page":"417","article-title":"Treatment of moderate to severe facial seborrheic dermatitis with itraconazole: an open non\u2010comparative study","volume":"10","author":"Shemer A","year":"2008","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.032"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1578-2190(07)70491-2"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S284671"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2019.02.001"},{"key":"e_1_2_11_11_1","volume-title":"Biological Function of Exosome\u2010Like Nanoparticles Isolated from rose (Rosa Damascena) stem cells culture (RSCE)","year":"2023"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16261"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2021.0146"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105490"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2023.2220444"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3666"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.12.065"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01624.x"},{"key":"e_1_2_11_19_1","volume-title":"IMCAS World Congress 2024","author":"Lueangarun S","year":"2024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030680"},{"issue":"5","key":"e_1_2_11_21_1","first-page":"15","article-title":"Efficacy and safety of a low molecular weight hyaluronic acid topical gel in the treatment of facial seborrheic dermatitis final report","volume":"7","author":"Schlesinger T","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0133-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439354"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16389","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16389","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:48:37Z","timestamp":1791506917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jocd.16389"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16389","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]},"assertion":[{"value":"2024-01-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}