{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:18Z","timestamp":1791507138496,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nonsurgical cosmetic procedures, particularly the use of hyaluronic acid (HA)\u2010based soft tissue fillers, are becoming increasingly popular. This trend has catalyzed the development of a plethora of HA\u2010based products differing in product characteristics, thereby catering to an ever\u2010widening spectrum of aesthetic applications. However, complications rise concomitant with the increasing number of procedures. Among the strategies to manage such adverse events is the enzymatic breakdown with hyaluronidase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the response of different HA\u2010based soft tissue filler materials to hyaluronidase injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 11 different HA\u2010based soft tissue fillers were evaluated using noninvasive ultrasound imaging to assess their behavior in response to hyaluronidase injections. The HA\u2010based soft tissue fillers were categorized according to their product characteristics into a structuring, volumizing, and lip volumizing group. Standardized injections of 0.2\u2009cc were performed in chicken breast to simulate human tissue. Ultrasound measurements of width, height, and calculated volume were performed immediately after filler injection, 1\u2009h and 24\u2009h following hyaluronidase injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Regardless of the soft tissue filler analyzed, the most significant volume reduction occurred within the first h after applying hyaluronidase, with a 64.1% decrease from the initial volume. After 24\u2009h, the total volume reduction reached 81.7%. No statistically significant differences were found when comparing the three groups at each follow\u2010up time period, except for the height measurement after 1\u2009h. While width was statistically significant in all groups between the investigated follow\u2010up groups, the volume reduction was only statistically significant in the groups with the highest and second highest G' values (i.e., Group 1\u2014structuring, Group 2\u2014volumizing).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The effectiveness of hyaluronidase in dissolving HA\u2010based fillers is initially independent of product characteristics of HA\u2010based fillers such as G\u2010prime, with increased efficacy in fillers with higher G\u2010prime values, as evidenced by significant volume reductions in such groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16393","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:40:11Z","timestamp":1716252011000},"page":"3173-3181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Resolve and dissolve\u2014An ultrasound\u2010guided investigation on the effects of hyaluronidase on different soft tissue fillers"],"prefix":"10.1111","volume":"23","author":[{"given":"Bruna S. F.","family":"Bravo","sequence":"first","affiliation":[{"name":"Department of Dermatology Bravo Private Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamires","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bravo Private Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bravo Private Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo G.","family":"Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bravo Private Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina","family":"Zafra","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bravo Private Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Calomeni","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bravo Private Clinic  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"International Society of Aesthetic Plastic Surgery.ISAPS International Survey On Aesthetic\/Cosmetic Procedures performed in 2021. ISAPS Global survey 2021.2022https:\/\/www.isaps.org\/media\/vdpdanke\/isaps\u2010global\u2010survey_2021.pdf"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/asjof\/ojad053"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1298787"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15453"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000000840"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1741560"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.01046.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002763"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810518"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1688797"},{"issue":"5","key":"e_1_2_11_12_1","first-page":"498","article-title":"Influence of rheological properties and needle size on extrusionforces of hyaluronic acid based soft\u2010tissue fillers","volume":"20","author":"Frank K","year":"2020","journal-title":"Dermatologic Surg"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2020.00731"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2020.00752"},{"issue":"6","key":"e_1_2_11_15_1","first-page":"E61","article-title":"This month's guideline: the use of hyaluronidase in aesthetic practice (v2.4)","volume":"11","author":"King M","year":"2018","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-016-0201-5"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000486"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjz053"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003851"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1721872"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.20517\/2347-9264.2020.133"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000002184"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005201"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000001154"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsc.2022.01.001"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/22925503211019618"}],"updated-by":[{"DOI":"10.1111\/jocd.71162","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000}}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:48:19Z","timestamp":1791506899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":25,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jocd.16393"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16393","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"2024-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}