{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:12:13Z","timestamp":1792019533711,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin aging and photoaging is a process that may appear at a relatively early age, causing an aesthetic problem. Common signs of skin aging include wrinkles, dyspigmentation, and decreased elasticity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Aim of this article is to study the effectiveness and safety of low\u2010level laser therapy (LLLT) for skin rejuvenation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty Syrian female patients aged 25\u201350 participated in this study and were diagnosed with moderate to severe melasma and wrinkles. The patients were divided into two groups and received LLLT with a wavelength of 660\u2009nm emitting a continuous wave. The power density and dose used were 15.6\u2009mW\/cm\n                      <jats:sup>2<\/jats:sup>\n                      , and 3\u2009J\/cm\n                      <jats:sup>2<\/jats:sup>\n                      respectively, and the laser effective area was 32\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      . The evaluation was done before, during, and after 12\u2009treatment sessions, based on photographs, in addition to the modified Melasma Area Severity Index (MASI), Pinch test, and Fitzpatrick's classification of facial wrinkling at baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Comparing before, and after treatment, and between the two groups, revealed a significant improvement in skin rejuvenation, with a statistical significance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Additional outcome measures included assessments of patient satisfaction scores, and no adverse effects or re\u2010pigmentation were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that LLLT may be a useful and safe therapeutic option in treating melasma, skin elasticity, and wrinkle improvement, which we advised to be integrated into treatment, and follow\u2010up programs in cosmetics and dermatology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16404","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T01:34:09Z","timestamp":1717119249000},"page":"3234-3240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Low\u2010level laser therapy for skin rejuvenation: A safe and effective solution baked by data 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