{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:16Z","timestamp":1791507136200,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100012543","name":"Shanghai Science and Technology Development Foundation","doi-asserted-by":"publisher","award":["16411961400"],"award-info":[{"award-number":["16411961400"]}],"id":[{"id":"10.13039\/100012543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy and safety of a repairing mask as an adjunctive treatment for skin barrier maintenance of mild to moderate rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with rosacea were recruited in this dual center randomized controlled trial from November 2019 to December 2021. A total of 64 patients were included and randomized into two groups at a ratio of 3:1 into a mask group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200947) and a control group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200917). Patients in the mask group received treatment with Dr. Yu\n                      <jats:italic>Centella asiatica<\/jats:italic>\n                      repairing facial mask three times weekly for a duration of 6\u2009weeks. All participants were instructed to continue their regimen of 50\u2009mg oral minocycline twice daily and to apply Dr. Yu Intensive Hydrating Soft Cream twice daily. The primary endpoint of this study was the Investigator Global Assessment (IGA) score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 54 patients completed this trial, with 41 in the mask group and 13 in the control group. After using this facial mask for 3 and 6\u2009weeks, the IGA, facial skin dryness, facial flushing, and severity of skin lesion in the mask group showed significantly improvement (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Moreover, the change in the delta degree of skin flushing was significantly higher than that in the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Throughout the study, no adverse events were reported in either group of participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The Dr. Yu\n                      <jats:italic>Centella asiatica<\/jats:italic>\n                      repairing facial mask, as an adjunctive treatment of rosacea, appears to effectively repair and protect the skin barrier, alleviate cutaneous symptoms of rosacea, and is both efficacious and safe for patient use.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16413","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T01:44:27Z","timestamp":1717465467000},"page":"3281-3286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A two\u2010center randomized controlled trial of a repairing mask as an adjunctive treatment for mild to moderate rosacea"],"prefix":"10.1111","volume":"23","author":[{"given":"Liwei","family":"Wang","sequence":"first","affiliation":[{"name":"Skin and Cosmetics Research Laboratory Skin Disease Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Skin and Cosmetics Research Laboratory Skin Disease Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengfeng","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Jahwa United Co., LTD  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiamei","family":"Feng","sequence":"additional","affiliation":[{"name":"Shanghai Jahwa United Co., LTD  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Skin and Cosmetics Research Laboratory Skin Disease Hospital of Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16481"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00595-7"},{"key":"e_1_2_12_4_1","unstructured":"Guidelines for the diagnosis and treatment of rosacea in China (2021 edition) [in Chinese]. International Journal of Dermatology and Venereology2021."},{"key":"e_1_2_12_5_1","unstructured":"Guidelines for the diagnosis and treatment of rosacea in China (2016 edition) [in Chinese]. Chin J Dermatol2017."},{"issue":"4","key":"e_1_2_12_6_1","first-page":"232","article-title":"Intervention of Yuze Skin Barrier repair agent on atopic dermatitis in children [in Chinese]","volume":"13","author":"Yanqiu YU","year":"2014","journal-title":"Chinese Journal of Dermatovenerology of Integrated Traditional and Western Medicine"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12851"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-018-2620-x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/term.1992"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.180247"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13020276"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19063266"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2013.0040"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.07.098"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23363"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:47:58Z","timestamp":1791506878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jocd.16413"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16413","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]},"assertion":[{"value":"2023-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}