{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:20Z","timestamp":1791507140619,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate the effect of isotretinoin (ISO) on NF\u2010\u03baB\/NLRP3, biotinidase, and HMGB and correlation with depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>This was a case\u2013control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20\u2009mg ISO for 2\u2009months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant's level of depression. Nuclear factor kappa B (NF\u2010\u0138B), biotinidase, high mobility group box protein (HMGB1), nucleotide\u2010binding domain, leucine\u2010rich\u2013containing family, and pyrin domain\u2013containing\u20103 (NLRP\u20133) were measured in serum samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no significant difference in all measured markers of healthy group before and after 2\u2009months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2\u2009months of treatment and significant correlations between GAGS, NF\u2010\u0138B, HMGB1, NLRP3, biotinidase, and depression score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16433","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T04:44:21Z","timestamp":1719204261000},"page":"3409-3417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Correlation between depression scores and serum\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u0138B<\/scp>\n                    \/\n                    <scp>NLRP3<\/scp>\n                    axis, biotinidase, and\n                    <scp>HMGB1<\/scp>\n                    after treatment with isotretinoin in patients with acne vulgaris"],"prefix":"10.1111","volume":"23","author":[{"given":"Ammena Y.","family":"Binsaleh","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Princess Nourah bint Abdulrahman University, P.O. Box\u00a084428  Riyadh 11671 Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahin Saad","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Faculty of Dentistry Al\u2010Ahliyya Amman University  Amman Jordan"},{"name":"Physiology Department, Faculty of Medicine Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-4573","authenticated-orcid":false,"given":"Mostafa M.","family":"Bahaa","sequence":"additional","affiliation":[{"name":"Pharmacy Practice Department, Faculty of Pharmacy Horus University  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaa A.","family":"Elmasry","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy Tanta University  Tanta Al\u2010Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A.","family":"Negm","sequence":"additional","affiliation":[{"name":"Pharmacognosy Department, Faculty of Pharmacy Tanta University  Tanta Al\u2010Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir O.","family":"Hamouda","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Faculty of Pharmacy Horus University  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed M.","family":"Salahuddin","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Pharmacology, Faculty of Pharmacy Horus University  New Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Wahsh","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Department, Faculty of Pharmacy Sinai University  Arish Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Ahmed","family":"El\u2010samongy","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Tanta University  Tanta Al\u2010Gharbia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawal","family":"Alsubaie","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Pharmacy Princess Nourah bint Abdulrahman University, P.O. 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