{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:18Z","timestamp":1791507138430,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Omega\u20103 fatty acids (\u03c9\u20103 FA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are essential nutrients known for their anti\u2010inflammatory properties, which involve reducing pro\u2010inflammatory cytokines, eicosanoids, and insulin\u2010like growth factor\u20101. This suggests their potential to alleviate acne severity, especially when deficits are present.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To elevate EPA\/DHA levels in acne patients through dietary intervention and supplementation, observing subsequent clinical effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Over 16\u2009weeks, 60 patients without prescription medication (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923 acne comedonica [AC],\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200937 acne papulopustulosa [AP]) adhered to a Mediterranean diet, incorporating oral algae\u2010derived \u03c9\u20103 FA supplementation (600\u2009mg DHA\/300\u2009mg EPA week 1\u20138, 800\u2009mg DHA\/400\u2009mg EPA week 8\u201316). At four visits (V1\u2013V4), blood EPA\/DHA levels were tracked using the HS\u2010omega 3 index\u00ae (EPA\/DHA (%) of total identified fatty acids in erythrocytes; target 8%\u201311%, deficit &lt;8%, severe deficit &lt;4%), alongside clinical assessments and standardized questionnaires.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, 98.3% of patients had an EPA\/DHA deficit, with the mean HS\u2010omega 3 index\u00ae rising from 4.9% at V1 to 8.3% at V4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). AC showed significantly higher indices than AP at V4 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Objective improvements in both inflammatory and non\u2010inflammatory lesions were observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). While self\u2010reported appearance worsened in four patients, overall quality of life improved (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), particularly in AP. Dietary triggers were more clearly defined than beneficial foods. Intake of cow's milk and dairy products reduced (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Compliance was good; no adverse events were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Many acne patients have a \u03c9\u20103 FA deficit. The HS\u2010omega 3 index\u00ae can be increased by a Mediterranean diet and oral supplementation with algae\u2010derived \u03c9\u20103 FA. Acne severity improved significantly in patients with target \u03c9\u20103 FA levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16434","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T03:02:43Z","timestamp":1720580563000},"page":"3295-3304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring the potential of omega\u20103 fatty acids in acne patients: A prospective intervention study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-0526","authenticated-orcid":false,"given":"Anne","family":"Guertler","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Neu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Lill","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Clanner\u2010Engelshofen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, University Hospital LMU Munich  Munich Germany"},{"name":"Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miller School of Medicine University of Miami  Coral Gables 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