{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:24:14Z","timestamp":1790997854578,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2409804"],"award-info":[{"award-number":["2022YFC2409804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Poly L\u2010lactic acid (PLLA) can stimulate fibrous tissue regeneration to exert a filling effect. However, severe inflammatory reactions and unsatisfactory effects remain a concern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Herein, we describe the mechanism of action, efficacy, and safety of PLLA microspheres in suspension (PLLA\u2010b\u2010PEG\/HA) for facial contouring and soft tissue augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PLLA\u2010b\u2010PEG\/HA, ssynthesized by copolymerization with ethylene glycol, were suspended in hyaluronic acid (HA). Physiological verification was performed using scanning electron microscopy and X\u2010ray computed tomography. PLLA\u2010b\u2010PEG\/HA were subcutaneously injected into the dorsal region of 4\u2010month\u2010old rabbits. Ultrasound assessed volumetric capacity at 3\u2009days and 1, 2, 4, and 12\u2009weeks. The inflammatory response, collagen production, and HA degradation were evaluated. A retrospective case series of 10 patients who received PLLA\u2010b\u2010PEG\/HA injections was conducted to assess long\u2010term efficacy and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PLLA\u2010b\u2010PEG exhibited a spherical structure with a smooth surface (20\u201345\u2009\u03bcm diameter). In rabbits, implant site volume increased within 4\u2009weeks, gradually decreasing thereafter. Fibrous capsules, microvessel density, and new collagen fiber formation progressively increased at 4, 12, and 26\u2009weeks after injection. Clinical data demonstrated significant improvements in face contouring at months 3 and 12 after injection. All patients showed improved internal contours based on the Global Aesthetic Improvement Scale. After 12\u2009months, 90% of the patients retained good shaping and support effects with minimal adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PLLA\u2010b\u2010PEG\/HA demonstrated superior biocompatibility and facial regeneration potential, with outstanding dual collagen\u2010stimulating properties. The clinical efficacy and safety of PLLA\u2010b\u2010PEG\/HA have been validated and established as a promising therapeutic option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16446","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T16:40:41Z","timestamp":1721666441000},"page":"3508-3516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinical applications of a novel poly\u2010L\u2010lactic acid microsphere and hyaluronic acid suspension for facial depression filling and rejuvenation"],"prefix":"10.1111","volume":"23","author":[{"given":"Diya","family":"Su","sequence":"first","affiliation":[{"name":"Plastic &amp; Aesthetic Surgery Center Dalian University Affiliated Xinhua Hospital  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5704-2277","authenticated-orcid":false,"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Huaxia Medical Beauty Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"He","sequence":"additional","affiliation":[{"name":"Bejing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Wu","sequence":"additional","affiliation":[{"name":"Medical Department Imeik Technology Development Co., Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyan","family":"Zou","sequence":"additional","affiliation":[{"name":"Medical Department Imeik Technology Development Co., Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[{"name":"Bejing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhi","family":"Li","sequence":"additional","affiliation":[{"name":"Bejing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Bejing Engineering Lab of Neo\u2010Biodegradable Materials  Beijing China"},{"name":"Medical Department Imeik Technology Development Co., Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Lai","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory of Human Tissue Regeneration and Repair PKU\u2010HKUST ShenZhen\u2010HongKong Institution  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieqing","family":"Wang","sequence":"additional","affiliation":[{"name":"Plastic &amp; Aesthetic Surgery Center Dalian University Affiliated Xinhua Hospital  Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8332631"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00231"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.03.005"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26154429"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12301"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16229"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-012-9920-3"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.2022.6180"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.12788\/cutis.0555"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2020.32.6.519"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2020.123370"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2021.123720"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.01.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbab042"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-019-01562-8"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S315076"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000003505"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-008-9182-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15156"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1067-5410"},{"key":"e_1_2_11_23_1","first-page":"880","article-title":"Practices in the usage and reconstitution of poly\u2010L\u2010lactic acid","volume":"18","author":"Lin MJ","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e328348c1cb"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2009.10"},{"key":"e_1_2_11_26_1","first-page":"284","article-title":"Aging and facial changes\u2014documenting clinical signs, part 1: clinical changes of the aging face","volume":"10","author":"Nkengne A","year":"2012","journal-title":"Skinmed"},{"key":"e_1_2_11_27_1","first-page":"929","article-title":"Recommendations on the use of injectable poly\u2010L\u2010lactic acid for skin laxity in off\u2010face areas","volume":"18","author":"Haddad A","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2016.03.016"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2017.1358459"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.01.037"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12447"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.11.029"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035199"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T05:15:58Z","timestamp":1730265358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jocd.16446"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16446","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"assertion":[{"value":"2024-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}