{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:47:40Z","timestamp":1791895660531,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Dysbiosis of the skin microbiota has been identified as a key factor in the development of acne. This study was aimed to evaluate the effect of a facial cream gel containing a biotechnological phytocomplex, niacinamide and succinic acid on the bacterial diversity of subjects with mild\u2013moderate acne and its clinical benefits due to microbiota changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Open\u2010label, clinical study in 44 subjects with mild\u2013moderate acne treated with a facial cream gel for 8\u2009weeks. Bacterial diversity was analyzed by <jats:italic>16S rRNA<\/jats:italic> gene sequencing of skin samples. Clinical effects were evaluated using the IGA acne severity scale, biometric measurements, and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 56\u2009days of product's use, an increase in alpha and beta diversity was found (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), with a decrease in the relative abundance of <jats:italic>C. acnes<\/jats:italic> (48.99% vs. 38.83%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Regarding clinical results, a decrease in acne severity on the IGA scale (27.33%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), number of non\u2010inflammatory and inflammatory lesions (respectively: 31.12%, <jats:italic>p<\/jats:italic>\u2009=\u20090.05; 47.27%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), amount of sebum (89.00%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and erythema (15.35%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), was found. [Correction added on 19 September 2024, after first online publication: In the preceding sentence, \u201c42.27%\u201d has been changed to \u201c47.27%\u201d in this version.] Responder analysis of the IGA score showed that 61.36% of patients improved by at least one point at day 56. The product was well tolerated throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of the facial cream gel on skin was effective in rebalancing the microbiota, inhibiting biofilm formation and other virulence factors, reducing the number of mild\u2013moderate acne lesions and sebum secretion, and consequently improving acne's severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16452","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T06:55:23Z","timestamp":1724914523000},"page":"3616-3627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["New clinical approach in facial mild\u2013moderate acne: Re\u2010stabilization of skin microbiota balance with a topical biotechnological phytocomplex"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7929-362X","authenticated-orcid":false,"given":"Raul","family":"De Lucas","sequence":"first","affiliation":[{"name":"Hospital Universitario La Paz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5947-6888","authenticated-orcid":false,"given":"Helena","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre, S.A.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6871-2288","authenticated-orcid":false,"given":"Carlos","family":"Nieto","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre, S.A.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Ruiz\u2010Alonso","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre, S.A.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Bermejo","sequence":"additional","affiliation":[{"name":"Laboratorio Reig Jofre, S.A.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Carr\u00f3n","sequence":"additional","affiliation":[{"name":"Microomics Systems S.L.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-2938","authenticated-orcid":false,"given":"Sergio","family":"Garcia\u2010Segura","sequence":"additional","affiliation":[{"name":"Microomics Systems S.L.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Gonzalez\u2010Torres","sequence":"additional","affiliation":[{"name":"Microomics Systems S.L.  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-9365","authenticated-orcid":false,"given":"David","family":"Palacios\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Salud Universitario Isabel II  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5504-1382","authenticated-orcid":false,"given":"Aurora","family":"Guerra\u2010Tapia","sequence":"additional","affiliation":[{"name":"Consulta Dermat\u00f3logas Guerra Universidad Complutense de Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola","family":"Bou","sequence":"additional","affiliation":[{"name":"Consulta de Dermatolog\u00eda  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montse","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Dermatol\u00f3gica de Moragas  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002533"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-021-14593-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abo0693"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00531-1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13279"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102523"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071303"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1324930"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8111752"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2019.3535"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0186-5"},{"key":"e_1_2_10_13_1","first-page":"46","article-title":"Quorum sensing modulation: new mechanism of action to balance the skin microbiome Dysbiosis","volume":"145","author":"Exp\u00f3sito O","year":"2019","journal-title":"SOFW Journal"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1654075"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0533-3"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10349-w"},{"issue":"1","key":"e_1_2_10_17_1","first-page":"27","article-title":"Microbiome quorum sensing modulation \u2013 a genuine mechanism of action to rebalance the skin microbiota Dysbiosis from a new paradigm: shoot the message not the messenger","volume":"22","author":"Exp\u00f3sito O","year":"2019","journal-title":"International Federation of Societies of Cosmetic Chemists"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45050255"},{"key":"e_1_2_10_19_1","first-page":"P013","article-title":"Anti\u2010inflammatory and anti\u2010quorum sensing effect of a novel biotech ingredient for treatment of acne","volume":"45","author":"Ca\u00f1ellas\u2010Santos M","year":"2023","journal-title":"EADV Symposium"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2003"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0209-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3869"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009490"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm864"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1201.0490"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-020-03803-z"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v034.i02"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.133"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2427.2007.01925.x"},{"key":"e_1_2_10_33_1","unstructured":"OksanenJ BlanchetFG FriendlyM et\u00a0al.vegan: Community Ecology Package. R package version 2.5\u20136.2019https:\/\/CRAN.R\u2010project.org\/package=vegan"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8070987"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14729"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499858"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1167923"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T05:14:39Z","timestamp":1730265279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jocd.16452"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16452","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,28]]},"assertion":[{"value":"2024-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}