{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:52:03Z","timestamp":1771491123886,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Botulinum Toxin (BoNTA) is the most used nonsurgical aesthetic procedure to treat facial expression lines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study compared the efficacy of Prabotulinum toxin\u2010A, a novel BoNTA that originates from Clostridium botulinum Hall\u2010A, with onabotulinum toxin\u2010A in treating facial expression lines using the Facial Wrinkle Scale (FWS) and FACE\u2010Q questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an experimental, comparative, longitudinal, open\u2010label, and prospective study. Patients aged between 25 and 40\u2009years with upper\u2010third facial expression lines were included. Follow\u2010ups were made at three, seven, 30, and 120\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 26 patients were included: 20 female, and six males, with a mean age of 28.26\u2009years. An average of 31.00\u2009IU and 31.38\u2009IU were administered to the onabotulinum and prabotulinum groups, respectively. The prabotulinum group demonstrated superiority in FWS and Face\u2010Q scores between the first and third days (<jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, respectively), which continued on day 7. By day 30, there were no differences in the scores of the two questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prabotulinum toxin\u2010A is a safe and effective treatment for upper\u2010third facial wrinkles. On day three and seven, the results suggest that prabotulinum toxin\u2010A has a quicker onset of action than onabotulinum toxin\u2010A. On days 30 and 120, both groups showed similar FWS and Face\u2010Q scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16454","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:54:02Z","timestamp":1720677242000},"page":"3532-3538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparative study between the efficacy of prabotulinum toxin\u2010A versus onabotulinum toxin\u2010A for the treatment of upper facial expression lines"],"prefix":"10.1111","volume":"23","author":[{"given":"Nicte","family":"Rodriguez\u2010Chavez","sequence":"first","affiliation":[{"name":"Oculoplastic Department Instituto de Oftalmolog\u00eda, Fundaci\u00f3n Conde de Valenciana F. A. P  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-5264","authenticated-orcid":false,"given":"Edric","family":"Gonzalez\u2010Mondrag\u00f3n","sequence":"additional","affiliation":[{"name":"Oculoplastic Department Instituto de Oftalmolog\u00eda, Fundaci\u00f3n Conde de Valenciana F. A. P  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3714-4406","authenticated-orcid":false,"given":"Angel","family":"Nava\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Oculoplastic Department Instituto de Oftalmolog\u00eda, Fundaci\u00f3n Conde de Valenciana F. A. 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