{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T17:00:38Z","timestamp":1785085238364,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Botulinum neurotoxin (BoNT) injections are widely used for the treatment of masseter muscle hypertrophy in Southeast Asia. However, there remains a lack of consensus regarding the optimal injection technique. This study aimed to compare the efficacy and patient discomfort associated with single\u2010entry point injections versus multiple three\u2010point injections for masseter muscle hypertrophy treatment with BoNT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Sixteen participants, comprising both male and female Korean adults aged 22\u201363, were enrolled in the study. On the left side of the face, single\u2010entry point injections were administered, followed by multidirectional injections, while on the right side, three\u2010point injections were given. Pain intensity during the procedure was assessed using visual analogue scale scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Our results revealed that participants experienced lower levels of pain with single\u2010entry point injections compared to three\u2010point injections (average visual analogue scores of 3.31 and 5.19, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings highlight the potential benefits of single\u2010entry point injections in reducing patient discomfort during masseter muscle hypertrophy treatment with BoNT. We advocate for further research to validate these findings and encourage practitioners to consider single\u2010entry point injections as a viable option for enhancing treatment outcomes in their clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16461","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:49:34Z","timestamp":1721033374000},"page":"3539-3543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel single\u2010entry point injection technique for masseter hypertrophy treatment using botulinum neurotoxin based on patient\u2010reported comfort"],"prefix":"10.1111","volume":"23","author":[{"given":"Jovian","family":"Wan","sequence":"first","affiliation":[{"name":"Asia Pacific Aesthetic Academy  Hong Kong Hong 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