{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:03:23Z","timestamp":1788192203125,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia (AGA) is common. While topical minoxidil remains the only FDA\u2010approved therapeutic for AGA, its efficacy is limited in stimulating clinically significant hair regrowth over the longer term. Oral minoxidil, which is used off\u2010label, is a promising alternative; however, its effectiveness and underlying mechanisms warrant further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To elucidate the site of action and infer the physiological mechanisms underlying therapeutic responses to oral minoxidil in patients with AGA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010one patients with AGA underwent 6\u2009months of low\u2010dose oral minoxidil treatment. Minoxidil sulfotransferase (SULT) activity was assayed in plucked scalp hair follicles. The primary outcome was hair growth after low\u2010dose oral minoxidil treatment for a minimum of 6\u2009months, and the secondary outcome was SULT activity in hair follicles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 6\u2009months of treatment, 26 (63.4%) patients experienced a clinical improvement in alopecia symptoms. The response rate was higher in men (19\/26 [73.1%]) than in women (6\/15 [40.0%]). Patients with low hair follicle SULT activity demonstrated a higher minoxidil response rate than those with high enzyme activity (85% vs. 43%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that low SULT activity within the hair follicles is associated with a favorable response to oral minoxidil therapy in patients with AGA. Further elucidation of the underlying mechanisms could significantly improve personalized therapeutic approaches through improved patient selection and the rational design of adjuvant treatments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16473","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T03:23:10Z","timestamp":1721618590000},"page":"3767-3773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hair follicle sulfotransferase activity and effectiveness of oral minoxidil in androgenetic alopecia"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-0147","authenticated-orcid":false,"given":"Juan","family":"Jimenez\u2010Cauhe","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Va\u00f1o\u2010Galvan","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7745-9993","authenticated-orcid":false,"given":"Nina","family":"Mehta","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hermosa\u2010Gelbard","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ortega\u2010Quijano","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Buendia\u2010Casta\u00f1o","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-1770","authenticated-orcid":false,"given":"Diego","family":"Fern\u00e1ndez\u2010Nieto","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Porri\u00f1o\u2010Bustamante","sequence":"additional","affiliation":[{"name":"Trichology Unit Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Saceda\u2010Corralo","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pindado\u2010Ortega","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar M.","family":"Moreno\u2010Arrones","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Ramon y Cajal, IRYCIS Universidad de Alcala, Spain; Trichology Unit, Grupo de Dermatologia Pedro Jaen  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-4489","authenticated-orcid":false,"given":"Carlos","family":"Wambier","sequence":"additional","affiliation":[{"name":"Department of Dermatology Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachita","family":"Dhura","sequence":"additional","affiliation":[{"name":"Department of Dermatology LTM Medical College and Hospital Sion  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[{"name":"University of Rome (\u201cG. Marconi\u201d)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-2289","authenticated-orcid":false,"given":"Andy","family":"Goren","sequence":"additional","affiliation":[{"name":"University of Rome (\u201cG. Marconi\u201d)  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"StatPearls","author":"Ho CH","year":"2024"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2196"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S385861"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.119104"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-023-00919-x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1009"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17216"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-5926-11-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12686"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15891"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S214907"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12130"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12164"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5768"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00673.x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15980"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.idoj_246_22"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00111"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.123.001275"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-015-0020-3"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.10.11.13444"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241311198"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16765"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16645"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13195"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.33589\/33.3.93"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14299"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2020.100050"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12915"},{"issue":"4","key":"e_1_2_12_32_1","first-page":"937","article-title":"The effect of topical minoxidil treatment on follicular sulfotransferase enzymatic activity","volume":"32","author":"Andy G","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488011"},{"issue":"1","key":"e_1_2_12_34_1","first-page":"131","article-title":"Surgical treatment of insertional Achilles tendinopathy: a systematic review","volume":"30","author":"Francesco T","year":"2016","journal-title":"J Biol Regul Homeost Agents"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12111"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000211315"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2020.99947"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.202930"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.386"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14642"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.06.020"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529509093237"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03188857"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327197016001061"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T01:13:54Z","timestamp":1730250834000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/jocd.16473"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16473","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"assertion":[{"value":"2024-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}