{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:52:14Z","timestamp":1791507134427,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Androgenetic alopecia is the most common cause of hair loss that affects over 50% of the world population. It is a condition that is multifactorial in origin, with no specific causative factor, making treatment an enervating experience for the patient as well as the doctor. In recent times, a number of modalities have been introduced for the treatment of alopecia. However, the evidence supporting them is unstructured and sparse. Therefore, this article aims to explore the current trends in minimally invasive treatments for the management of androgenetic alopecia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An in\u2010depth literature search on injectables used in the treatment of alopecia in PubMed\/MEDLINE, Embase, PsycINFO, TRIP Cochrane Library, and Cochrane Skin databases between January 2000 and May 2023 was performed. The studies included were randomized controlled trials, non\u2010randomized trials, quasi trials, single arm interventions, and cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixteen of the 1071 studies that were found during the original search were accepted in accordance with the inclusion criteria. Twelve studies assessed the effectiveness of the injectable group by comparing it to a control group consisting of saline, distilled water, and topical minoxidil. In the treatment of alopecia, dutasteride and injectable growth factor formulations achieved clinically significant results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The usage of injectables and topical medicines to treat hair loss has increased in the recent years. Overall results from clinical investigations, pilot studies, and trials looking at the efficacy and safety of these growth factors in the AGA show satisfactory efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.16493","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:11:51Z","timestamp":1724393511000},"page":"3144-3157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["\u201cEffectiveness of minimally invasive injectable modalities in the management of androgenetic alopecia among adults\u2014A systematic review\u201d"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-1740","authenticated-orcid":false,"given":"Vaibhav","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Research The Esthetic Clinics  Mumbai Maharashtra India"},{"name":"Department of Public Health Dentistry Dr GD Pol Foundation YMT Dental College  Navi Mumbai Maharashtra India"},{"name":"Maastricht University Medical Centre Maastricht University  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael","family":"Gold","sequence":"additional","affiliation":[{"name":"Gold Skin Care Center, Tennessee Clinical Research Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-9663","authenticated-orcid":false,"given":"Anuj","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Dr. Hedgewar Smruti Rugna Seva Mandal's Dental College and Hospital  Hingoli Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranjal","family":"Mhatre","sequence":"additional","affiliation":[{"name":"Department of Research The Esthetic Clinics  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ungku Mohd Shahrin b Mohd","family":"Zaman","sequence":"additional","affiliation":[{"name":"Medicine, Bioscience and Nursing Faculty MAHSA University  Kuala Lumpur Malaysia"},{"name":"USMARI Centre  Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinky","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cosmetic Dermatology and Dermatosurgery The Esthetic Clinics  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-1170","authenticated-orcid":false,"given":"Debraj","family":"Shome","sequence":"additional","affiliation":[{"name":"Department of Facial Plastic Surgery and Facial Cosmetic Surgery The Esthetic Clinics  Mumbai Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14537"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116730"},{"key":"e_1_2_10_4_1","volume-title":"Endotext","author":"Asfour L","year":"2000"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13673"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002843"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/der2.109"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1439965"},{"issue":"11","key":"e_1_2_10_9_1","first-page":"E64","article-title":"A systematic review and meta\u2010analysis of randomized controlled trials of United States Food and Drug Administration\u2010approved, home\u2010use, low\u2010level light\/laser therapy devices for pattern hair loss: device design and technology","volume":"14","author":"Lueangarun S","year":"2021","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14624"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80052-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14867"},{"key":"e_1_2_10_13_1","first-page":"1308","article-title":"Hair regrowth following a Wnt\u2010 and follistatin containing treatment: safety and efficacy in a first\u2010in\u2010man phase 1 clinical trial","volume":"10","author":"Zimber M","year":"2011","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002168"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.23812\/19-385-L-51"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-111066"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118715598.ch7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"e_1_2_10_19_1","unstructured":"The Cochrane collaboration.Review Manager (RevMan).2020."},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-2197.2003.02748.x"},{"key":"e_1_2_10_21_1","unstructured":"AbdallahM El\u2010ZawahryK BesarH.Mesotherapy using dutasteride\u2010containing solution in male pattern hair loss: a controlled pilot study.2009;20:1."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13398"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14139"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181ef816d"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.4103\/JCAS.JCAS_77_17"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.04.082"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1501893"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14622"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12501"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijt.ijt_89_18"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1322552"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4314\/aas.v14i1.8"},{"issue":"4","key":"e_1_2_10_33_1","first-page":"457","article-title":"A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women","volume":"17","author":"Lee SW","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04535.x"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2010.10.015"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-009-9423-z"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.2.197"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.012"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14154"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-021-02201-6"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12382494"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0733-8635(05)70384-3"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S334807"},{"key":"e_1_2_10_44_1","unstructured":"FDA.Public Safety Notification on Exosome Products.2019. Accessed August 18 2023.https:\/\/www.fda.gov\/vaccines\u2010blood\u2010biologics\/safety\u2010availability\u2010biologics\/public\u2010safety\u2010notification\u2010exosome\u2010products"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.16493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:47:44Z","timestamp":1791506864000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/jocd.16493"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16493","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2024-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}