{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T16:39:29Z","timestamp":1781368769423,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Solar lentigo is a prevalent skin condition that affects a significant number of individuals. Fortunately, certain traditional Chinese medicines and monomers (TCMM) have proven effective in addressing these concerns. In this study, we evaluated the efficacy and underlying mechanism of TCMM, a combination of TCM and monomers in repairing solar lentigo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We detected and identified the main compounds of TCM using liquid chromatography\u2010mass spectrometry (LC\u2013MS) and through the approach of network pharmacology, we screened drug and disease targets, visualized networks with Cytoscape software, analyzed targets via Gene ontology and KEGG, clinically validated predictions. In a mouse model, UVB\u2010induced pigmentation was assessed, and the effects of TCMM were evaluated. A clinical trial on 30 patients validated the depigmenting agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Active ingredients such as MSH, Butylated hydroxytoluen, Valerophenone, and Geranylacetone aid pigmentation treatment. One hundred and forty\u2010three crore targets impact PI3K\u2010Akt, MAPK signaling pathway, ect. pathways. TCMM reduced UVB\u2010induced pigmentation, water loss, epidermal thickness, and melanin. It inhibited TYR, MITF, AKT1, VEGFA, PTGS2, TNF\u2010\u03b1, IL\u20106, IL\u20101\u03b2. Clinical and microscopic analysis showed significant pigmentation reduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The treatment of solar lentigo can benefit from the TCMM. By targeting multiple factors and pathways, this approach offers a comprehensive and effective treatment strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16507","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T08:56:06Z","timestamp":1725958566000},"page":"4029-4042","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of traditional Chinese medicines in the treatment of solar lentigo based on network pharmacology and experimental validation"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6016-3775","authenticated-orcid":false,"given":"Dongmei","family":"Wu","sequence":"first","affiliation":[{"name":"The School of Biomedical and Pharmaceutical Engineering Guangdong University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Lv","sequence":"additional","affiliation":[{"name":"Infinitus Company Ltd., R&amp;D Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Han","sequence":"additional","affiliation":[{"name":"Foshan Conney Allan Biotechnology Co. Ltd  Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingna","family":"Xie","sequence":"additional","affiliation":[{"name":"The School of Biomedical and Pharmaceutical Engineering Guangdong University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"The School of Biomedical and Pharmaceutical Engineering Guangdong University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congwei","family":"Ma","sequence":"additional","affiliation":[{"name":"The School of Biomedical and Pharmaceutical Engineering Guangdong University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Tai","sequence":"additional","affiliation":[{"name":"Infinitus Company Ltd., R&amp;D Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang indigenous medicinal plants resource utilization, CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences  Urumqi China"},{"name":"University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[{"name":"Foshan Conney Allan Biotechnology Co. 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