{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:29:19Z","timestamp":1788236959424,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond\u2010Augmented Zinc Oxide (ND\u2010ZnO) technology combines zinc oxide with diamond particles in a unique core\u2010shell structure, offering a multifaceted approach to overall skin health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study evaluates the efficacy of ND\u2010ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In vitro assays assessed wound healing, collagen production, and skin absorption. Human Dermal Fibroblasts (HDFs) were used in scratch wound assays. Collagen synthesis was quantified using enzyme\u2010linked immunosorbent assays (ELISA). Permeation tests were performed on reconstructed human epidermal tissues to evaluate niacinamide absorption. Clinical case studies validated ND\u2010ZnO efficacy in post\u2010CO<jats:sub>\u2082<\/jats:sub> laser treatments and Actinic Keratosis removal recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ND\u2010ZnO increased HDF migration by 198% compared to controls. Collagen synthesis assays showed a 71.3% restoration of collagen production in aged HDFs. Skin permeation studies revealed a 203% increase in niacinamide skin absorption with ND\u2010ZnO. Clinical case studies demonstrated faster and more effective healing post\u2010ablative CO\u2082 laser and significant improvements in Actinic Keratosis recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ND\u2010ZnO technology enhances wound healing, collagen synthesis, and active ingredient delivery, offering substantial benefits for daily skin regeneration and other dermatological applications. This innovative approach holds promise for advancing dermatological therapeutics, providing comprehensive skin care solutions that address both protective and regenerative needs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16508","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T16:54:57Z","timestamp":1722444897000},"page":"4043-4050","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Enhanced skin regeneration and therapeutic delivery using novel diamond\u2010augmented zinc oxide"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-8334","authenticated-orcid":false,"given":"Xinge Diana","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Applied Sciences and Engineering Harvard University  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Teng","sequence":"additional","affiliation":[{"name":"B.A.I. 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Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4331-8305","authenticated-orcid":false,"given":"Suneel","family":"Chilukuri","sequence":"additional","affiliation":[{"name":"Refresh Dermatology  Houston Texas USA"},{"name":"Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4464-8501","authenticated-orcid":false,"given":"Amy","family":"Lewis","sequence":"additional","affiliation":[{"name":"Lewis Dermatology  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-5433","authenticated-orcid":false,"given":"Michael H.","family":"Gold","sequence":"additional","affiliation":[{"name":"Gold Skin Care Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_13_2_1","first-page":"9","article-title":"Deciphering the focuses and trends in skin regeneration research through bibliometric analyses","volume":"9","author":"Zhou J","year":"2022","journal-title":"Front Med"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12300"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.07.020"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3565127"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSA.S19419"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2130.2004.00115.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcs7090385"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym11071214"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102609"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpra.2024.01.006"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2022.05.008"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a023267"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.03.1677"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/15216540500091890"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.16508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:32:59Z","timestamp":1741761179000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.16508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/jocd.16508"],"URL":"https:\/\/doi.org\/10.1111\/jocd.16508","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2024-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}