{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T02:00:09Z","timestamp":1777082409226,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Macular amyloidosis is a form of primary localized cutaneous amyloidosis presented by pruritic pigmented macules in rippled or reticulate pattern. The aim of this study was to assess the efficacy of using topical tranexamic acid with micro\u2010needling comparing to micro\u2010needling alone in patients with macular amyloidosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with bilaterally located macular amyloidosis on trunk or upper extremities were recruited in this trial. The skin lesions in all patients were divided into two parts which were randomly assigned to the group of treatment with micro\u2010needling plus tranexamic acid and the group of micro\u2010needling alone. There were four sessions of treatment with 2\u2009weeks interval. The percentage of improvement in pigmentation (based on photographs and dermoscopy) and rippling of each group was determined by three blinded dermatologists. The level of patient satisfaction and reduction of pruritus was measured by a questionnaire and defined as a percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty females were enrolled in this study. The mean (SD) patients' age was 39.7 (\u00b110.13) years. Both groups showed improvement in pigmentation based on images, dermoscopy, and rippling pattern. Patients' satisfaction was 46.5% in tranexamic acid group and 47.5% in micro\u2010needling alone. Nevertheless, there was no significant difference between both groups (<jats:italic>p<\/jats:italic> value &gt;0.05). Interestingly, the pruritus improved 61.66% after four sessions of treatment in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Micro\u2010needling is a suitable modality for decreasing pruritus and pigmentation in macular amyloidosis. However, topical application of tranexamic acid does not lead to additional improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16517","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:06:42Z","timestamp":1722938802000},"page":"3968-3973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The effect of topical tranexamic acid with micro\u2010needling and micro\u2010needling alone in treatment of macular amyloidosis"],"prefix":"10.1111","volume":"23","author":[{"given":"Mehdi","family":"Gheisari","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-8082","authenticated-orcid":false,"given":"Fariba","family":"Ghalamkarpour","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-6788","authenticated-orcid":false,"given":"Shima","family":"Moslemi Haghighi","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirin","family":"Zaresharifi","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-2562","authenticated-orcid":false,"given":"Sahar","family":"Dadkhahfar","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran 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Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/idoj.IDOJ_507_19"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/pigmentinternational.pigmentinternational_5_22"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00620-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-020-02954-y"},{"issue":"4","key":"e_1_2_11_6_1","article-title":"Comparison of immunostaining with hematoxylin\u2010eosin and special stains in the diagnosis of cutaneous macular amyloidosis","volume":"12","author":"Aslani 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melasma: clinical, histopathologic, and immunohistochemical study","volume":"16","author":"Saleh FY","year":"2019","journal-title":"J Egypt"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1444770"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.01957.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1819527"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02473.x"}],"container-title":["Journal of Cosmetic 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