{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:27:43Z","timestamp":1758814063496,"version":"3.38.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sensitive skin is a highly prevalent problem. The objective of the study was to assess whether the tested products are effective and safe in terms of improving the symptoms of sensitive skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A clinical randomized split\u2010face study was carried out on 24 healthy female subjects. Three cosmetic combinations were tested versus vehicle: product A (Sol\u00eda Thermal Spring Water\u2013TSW\u2013from Cantabria, Spain\u2009+\u2009diatom algae\u2013<jats:italic>P. tricornutum<\/jats:italic>\u2013extract), product B (Sol\u00eda TSW\u2009+\u2009diatom algae extract\u2009+\u2009<jats:italic>Annona cherimola<\/jats:italic> Fruit Extract) and product C (Sol\u00eda TSW\u2009+\u2009diatom algae extract\u2009+\u2009<jats:italic>Annona cherimola<\/jats:italic> Fruit Extract\u2009+\u2009niacinamide). Prior to each application of the study Product (A, B, or C)\/vehicle, 10% of aqueous solution of capsaicin to induce skin irritation was applied, mimicking the symptoms of sensitive skin. Stinging and burning sensations were evaluated at different time points.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three tested products A, B, and C showed to act better in calming the symptoms induced by capsaicin when compared to the vehicle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The tested products would be an interesting option for treating stinging and burning sensations in sensitive skin patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16526","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:44:39Z","timestamp":1725533079000},"page":"4057-4065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Controlled comparison evaluation of the soothing effect of 3 cosmetic products on skin discomfort induced by an irritant chemical agent (capsaicin)"],"prefix":"10.1111","volume":"23","author":[{"given":"Maria","family":"Vitale","sequence":"first","affiliation":[{"name":"Medical Affairs Department Cantabria Labs  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0859-3536","authenticated-orcid":false,"given":"Ana","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"R&amp;D Department Cantabria Labs  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9691-0476","authenticated-orcid":false,"given":"Maria Teresa","family":"Truchuelo","sequence":"additional","affiliation":[{"name":"Vithas Nuestra Se\u00f1ora de Am\u00e9rica Hospital  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9147-302X","authenticated-orcid":false,"given":"Vincenzo","family":"Nobile","sequence":"additional","affiliation":[{"name":"R&amp;D Department Complife Italia S.r.l.  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7559-1202","authenticated-orcid":false,"given":"Massimo","family":"Milani","sequence":"additional","affiliation":[{"name":"Medical Department Cantabria Labs Difa Cooper  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"G\u00f3mez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Medical affairs Department Cantabria Labs  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16000"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpain.2022.853491"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.104664"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517525"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00754.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.m0922"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.11.006"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12245"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12442"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82624-3"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05764.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12819"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2011.04.011"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.01.011"},{"issue":"4","key":"e_1_2_13_16_1","first-page":"303","article-title":"Classification of sensitive skin and development of a treatment system appropriate for each group","volume":"6","author":"Yokota T","year":"2003","journal-title":"Int Fed Soc Cosmet Chemists"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1046-199x(97)90000-2"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00108"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-020-01647-x"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12204"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13156"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-2494.2005.00289_1.x"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13530"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics9060130"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9093047"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.10.002"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2010.00527.x"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19080464"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.4236\/ajps.2020.1110118"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics8030076"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80748-6"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186540"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9245420"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169238"},{"key":"e_1_2_13_35_1","unstructured":"Data on File. 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