{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:49:08Z","timestamp":1783712948071,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common inflammatory skin disease that occurs during puberty, affecting approximately 85% of young adults and may persist into adulthood. The pathophysiology of acne is multifactorial, involving hormonal, inflammatory, and immune mechanisms. Isotretinoin is widely used for treating severe cystic acne or recurrent acne. This medication is considered a pharmacological option that significantly reduces sebum secretion, leading to a reduction in the size of sebaceous glands. It also induces a lack of differentiation in sebaceous cysts, resulting in a decrease in lipid accumulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This research is a prospective study. Patient contact details were obtained directly from those visiting the dermatology clinic, and they were monitored for a duration of 3\u2009months. Essential data was gathered through patient examinations and inquiries at the clinic, including the prescription of tests prior to initiating isotretinoin treatment. Furthermore, follow\u2010up tests and examinations were performed within the initial and third months post\u2010treatment commencement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010two patients participated in the study, selected through non\u2010probability (convenience) sampling. The therapeutic dose taken by patients was 20\u2009mg of isotretinoin daily (<jats:italic>n<\/jats:italic>\u2009=\u200949) or every other day (<jats:italic>n<\/jats:italic>\u2009=\u200913). Among the participants, six patients experienced a decrease of 3\u2009units or more in HDL levels, while 16 patients saw an increase of 3\u2009units or more in LDL levels, 3\u2009months after beginning the treatment. Additionally, the triglyceride (TG) levels increased by 9\u2009units or more in six individuals, and the blood sugar (BS) levels increased by 5\u2009units or more in nine individuals, 3\u2009months after treatment initiation. Moreover, one person's waist circumference increased by 1.5\u2009cm 3\u2009months after treatment began. The average weight of the individuals at the end of the treatment rose from 60.74\u2009kg to 61.12\u2009kg. However, this weight increase was not statistically significant. (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In general, the results of our study show that the use of oral isotretinoin as a treatment option for the management of acne vulgaris can be effective when administered at the correct dosage, offering a safe and low\u2010complication option.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.16533","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T06:54:56Z","timestamp":1723704896000},"page":"4343-4348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigating metabolic syndrome markers and body mass index changes in patients with acne vulgaris treated with isotretinoin: A prospective study"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1102-6241","authenticated-orcid":false,"given":"Afsaneh Sadeghzadeh","family":"Bazargan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"},{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5878-9778","authenticated-orcid":false,"given":"Alireza","family":"Jafarzadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine Iran University of Medical Sciences (IUMS)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Danandeh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Iran university of Medical Sciences  Tehran 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